INT23660

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Context Info
Confidence 0.35
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 8.93
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap) plasma membrane (Fap)
Anatomy Link Frequency
neural 2
Fap (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 5 100.00 Very High Very High Very High
antagonist 2 99.04 Very High Very High Very High
Inflammation 27 82.08 Quite High
tetrodotoxin 1 81.44 Quite High
cytokine 3 81.04 Quite High
imagery 18 79.08 Quite High
abdominal pain 9 65.64 Quite High
Spinal cord 3 62.40 Quite High
Peripheral nervous system 6 59.24 Quite High
unmyelinated 3 58.24 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 720 100.00 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 63 100.00 Very High Very High Very High
Cancer 198 99.56 Very High Very High Very High
Adenoma 174 98.04 Very High Very High Very High
Shock 6 97.90 Very High Very High Very High
Targeted Disruption 24 97.48 Very High Very High Very High
Colon Cancer 99 97.32 Very High Very High Very High
Syndrome 27 97.20 Very High Very High Very High
Disease 96 95.32 Very High Very High Very High
Alzheimer's Dementia 96 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the FAP and SDP were abolished by Cd2+ and other Ca2+ antagonists.
Negative_regulation (abolished) of FAP associated with action potential and antagonist
1) Confidence 0.35 Published 1986 Journal J. Neurophysiol. Section Abstract Doc Link 2426420 Disease Relevance 0 Pain Relevance 0.40
In spite of the positive and exciting results obtained with this drug, doxycycline is not able to decrease all the FAP markers, and therefore we inferred that it would not perform optimally as a therapy for FAP.
Negative_regulation (decrease) of FAP associated with familial amyloidotic polyneuropathy
2) Confidence 0.27 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.52 Pain Relevance 0
Attenuated FAP is a milder form that is characterized by fewer adenomas, a later age of adenoma development and cancer diagnosis.


Negative_regulation (Attenuated) of FAP associated with adenoma, cancer and familial adenomatous polyposis
3) Confidence 0.26 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 2.42 Pain Relevance 0
Attenuated FAP is a milder form of FAP
Negative_regulation (Attenuated) of FAP associated with familial adenomatous polyposis
4) Confidence 0.26 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.70 Pain Relevance 0
A family member who is found to carry the mutation has 100% chance of developing FAP and its complications.
Negative_regulation (developing) of FAP associated with familial adenomatous polyposis
5) Confidence 0.26 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.63 Pain Relevance 0.11
Very recently, another FAP mouse model was generated, the V30M transgenic mice in a heat shock factor 1 (HSF-1) null background, representing a step forward in the study of this disorder; these mice represent an improved FAP model since animals showed TTR deposition in extra-neural and neural tissues, and recapitulated pathological findings in FAP.
Negative_regulation (represent) of FAP in neural associated with targeted disruption, familial amyloidotic polyneuropathy and shock
6) Confidence 0.23 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.33 Pain Relevance 0.22
Very recently, another FAP mouse model was generated, the V30M transgenic mice in a heat shock factor 1 (HSF-1) null background, representing a step forward in the study of this disorder; these mice represent an improved FAP model since animals showed TTR deposition in extra-neural and neural tissues, and recapitulated pathological findings in FAP.
Negative_regulation (represent) of FAP in neural associated with targeted disruption, familial amyloidotic polyneuropathy and shock
7) Confidence 0.08 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.33 Pain Relevance 0.22

General Comments

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