INT236620

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BRAF) plasma membrane (BRAF) nucleus (BRAF)
cytoplasm (BRAF)
BRAF (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 101 99.16 Very High Very High Very High
Sunburn 1 97.16 Very High Very High Very High
Cancer 37 82.56 Quite High
Cutaneous Melanoma 7 81.84 Quite High
Disease 33 56.48 Quite High
Colon Cancer 9 50.00 Quite Low
Metastasis 15 5.00 Very Low Very Low Very Low
Recurrence 14 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Generaliased Trisomy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, a third report has shown that mutations affecting either KRAS or BRAF are predictive and prognostic indicators in mCRC patients, and are inversely correlated with response to anti-EGFR monoclonal antibodies [16].
Regulation (affecting) of BRAF
1) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.36 Pain Relevance 0
The differential distribution of genetic alterations in BRAF, NRAS and KIT among melanoma subtypes according to anatomic sites and sun exposure strongly implicated different molecular pathways involved in tumorigenesis for each subtype (Antonescu et al, 2007).
Regulation (alterations) of BRAF associated with sunburn and melanoma
2) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880296 Disease Relevance 1.60 Pain Relevance 0

General Comments

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