INT236623

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BRAF) plasma membrane (BRAF) nucleus (BRAF)
cytoplasm (BRAF)
BRAF (Homo sapiens)
BRAF - V600E (1)
Pain Link Frequency Relevance Heat
metalloproteinase 4 95.60 Very High Very High Very High
Pain 2 87.76 High High
Glutamate 2 68.72 Quite High
palliative 5 52.96 Quite High
Sicca syndrome 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 161 99.84 Very High Very High Very High
Carcinoma 23 99.32 Very High Very High Very High
Cancer 89 97.00 Very High Very High Very High
Pain 2 87.76 High High
Melanoma 19 86.32 High High
Colon Cancer 10 50.00 Quite Low
Non-small-cell Lung Cancer 2 46.04 Quite Low
Small Cell Lung Cancer 2 45.76 Quite Low
Nevus 2 45.24 Quite Low
Metastasis 25 39.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As part of the eligibility requirements of the trial, paraffin-embedded tissue from a biopsy of a cutaneous lesion was tested and shown to be positive for the BRAF V600E mutation.
Positive_regulation (positive) of BRAF V600E (V600E)
1) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917408 Disease Relevance 0.76 Pain Relevance 0.09
Another study evaluating KRAS/BRAF mutation status in 80 patients receiving cetuximab as single-agent found only 3 KRAS mutated tumors out of 27 patients who experienced a clinical benefit, but 27 out of 53 nonresponding patients [15].
Positive_regulation (evaluating) of BRAF associated with cancer
2) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2432064 Disease Relevance 0.39 Pain Relevance 0
BRAF mutations in PTC
Positive_regulation (mutations) of BRAF associated with thyroid neoplasm
3) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.90 Pain Relevance 0.23

General Comments

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