INT236691

Context Info Confidence 0.20 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.46 Pain Relevance 0

mitochondrion (Cdk1) protein complex assembly (Cdk1) cytoplasm (Cdk1) mitosis (Cdk1) nucleus (Cdk1) cell cycle (Cdk1)

Cdk1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 9 27.40 cINOD 8 5.00 cytokine 4 5.00 anesthesia 3 5.00 isoflurane 3 5.00 COX2 2 5.00 Inflammation 2 5.00 aspirin 1 5.00 COX-2 inhibitor 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 15 80.48 Stress 3 71.64 Repression 4 67.44 Apoptosis 32 61.04 Cancer 52 57.68 Colon Cancer 22 5.00 Polyps 9 5.00 Familial Adenomatous Polyposis 8 5.00 Adenoma 6 5.00 Obesity 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.

Regulation (regulate) of Cdk1

1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0

However, the expressions of various genes involved in cell cycle regulation (PCNA, c-myc, CDK1, CDK4, and

Regulation (regulation) of CDK1

2) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.33 Pain Relevance 0

General Comments

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