INT236693

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Bcl6) nucleus (Bcl6) intracellular (Bcl6)
DNA binding (Bcl6)
Anatomy Link Frequency
B-cell 4
plasma cells 2
Bcl6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 92.28 High High
cytokine 4 65.84 Quite High
agonist 9 58.48 Quite High
cINOD 8 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 25 100.00 Very High Very High Very High
Otitis Media With Effusion 41 99.68 Very High Very High Very High
INFLAMMATION 14 92.28 High High
Cancer 105 86.16 High High
Leukemia 9 83.92 Quite High
Skin Cancer 4 82.12 Quite High
Infection 11 81.68 Quite High
Breast Cancer 8 80.68 Quite High
Disease 39 74.28 Quite High
Acute Promyelocytic Leukemia 1 73.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BCL-6 was first discovered as a gene translocated in a type of non-Hodgkin's lymphoma, but it has not been found in terminally differentiated plasma cells.28,29 We found that BCL-6 expression was significantly lower in the OME group, and that it was expressed primarily in the germinal centers.
Positive_regulation (lower) of Gene_expression (expression) of BCL-6 in plasma cells associated with lymphatic system cancer and otitis media with effusion
1) Confidence 0.15 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.58 Pain Relevance 0.05
corepressors, such as B-cell lymphoma 6 (BCL-6), silencing mediator for
Positive_regulation (as) of Gene_expression (corepressors) of BCL-6 in B-cell associated with lymphatic system cancer
2) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.39 Pain Relevance 0.10
BCL-6 is overexpressed in 40% of diffuse large B-cell lymphomas (Pasqualucci et al. 2003).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of BCL-6 in B-cell associated with lymphatic system cancer
3) Confidence 0.05 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.08 Pain Relevance 0

General Comments

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