INT236701

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.55
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
colon 2
pituitary glands 2
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 63.84 Quite High
cytokine 11 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 26 99.84 Very High Very High Very High
Targeted Disruption 31 99.52 Very High Very High Very High
Reprotox - General 1 5 98.96 Very High Very High Very High
Skin Cancer 14 98.92 Very High Very High Very High
Cancer 224 96.80 Very High Very High Very High
Pituitary Cancer 13 94.12 High High
Retinoblastoma 3 94.08 High High
Apoptosis 59 92.24 High High
Death 5 90.24 High High
Hyperplasia 7 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Crossbreeding of Rb (+/-) animals with PTTG1 transgenic animals showed enlarged pituitary glands and a 3.5-fold increase in the frequency of tumors originating from?
Negative_regulation (Crossbreeding) of Gene_expression (animals) of Rb in pituitary glands associated with targeted disruption and cancer
1) Confidence 0.10 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.34 Pain Relevance 0.03
with troglitazone also decreased the expression of several regulators of pRb
Negative_regulation (decreased) of Gene_expression (expression) of pRb
2) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.88 Pain Relevance 0
is activated by gossypol in prostate cancer cells, and gossypol upregulates p21 expression and downregulates cyclin D1 and Rb expression in colon cancer cells [8,9].
Negative_regulation (downregulates) of Gene_expression (expression) of Rb in colon associated with colon cancer and reprotox - general 1
3) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.18 Pain Relevance 0
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Negative_regulation (demonstrate) of Gene_expression (expression) of Rb associated with cancer
4) Confidence 0.05 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.14 Pain Relevance 0

General Comments

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