INT236711

Context Info Confidence 0.30 First Reported 2007 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 15 Total Number 16 Disease Relevance 12.98 Pain Relevance 0.58

cell morphogenesis (Bcl6) nucleus (Bcl6) intracellular (Bcl6) DNA binding (Bcl6)

Anatomy Link Frequency B-cell 3 epithelium 3 plasma cells 2 ciliated cells 1 Bcl6 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 123 99.00 Inflammatory response 16 89.80 cytokine 17 65.84 agonist 12 58.48 chemokine 3 47.56 fibrosis 19 5.00 Pain 12 5.00 alcohol 11 5.00 cINOD 8 5.00 imagery 6 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 157 100.00 B-cell Acute Lymphoblastic Leukemia 11 100.00 Otitis Media With Effusion 451 99.84 Metaplasia 143 99.78 Infection 150 99.68 Follicular Lymphoma 51 99.44 INFLAMMATION 144 99.00 Shock 4 98.80 Diffuse Large B-cell Lymphoma 10 98.44 Mantle-cell Lymphoma 35 97.76

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cases with neither BCL-2 or BCL-6 rearrangements compromise the third genetic group of DLBCL.

Gene_expression (rearrangements) of BCL-6 associated with diffuse large b-cell lymphoma

1) Confidence 0.30 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.31 Pain Relevance 0

Relative gene expression of four genes (Bcl6, Traf2 binding protein, heat shock protein 1B, and Cytochrome P450) was measured by qRTPCR.

Gene_expression (expression) of Bcl6 associated with shock

2) Confidence 0.27 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 0.70 Pain Relevance 0.03

The antigen profile includes CD20, CD19 and CD5 positive, and is BCL-2 and cyclin D1 positive but usually CD10 and BCL-6 negative.

Neg (negative) Gene_expression (negative) of BCL-6

3) Confidence 0.27 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.33 Pain Relevance 0

Therefore, OME may be due to alterations in the mucosal epithelium due to inflammatory reactions in the adenoids, and may influence the expression of BCL-6, which controls antibody production in the germinal centers of adenoids.

Gene_expression (expression) of BCL-6 in epithelium associated with inflammation and otitis media with effusion

4) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.72 Pain Relevance 0.05

Since we measured BCL-6 expression only after antigen stimulation, and since BCL-6 staining occurred primarily in the germinal centers, it may be that this transcription factor directly controls IgA production in the germinal centers.

Gene_expression (expression) of BCL-6

5) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.73 Pain Relevance 0.07

In conclusion, we observed significant decreases in the respiratory epithelium of adenoid mucosa, significant increases of squamous epithelial metaplasia, and significant reductions of BCL-6 expression in OME patients.

Gene_expression (expression) of BCL-6 in epithelium associated with metaplasia and otitis media with effusion

6) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.80 Pain Relevance 0.07

However, IgA secretion was not increased significantly in the OME group, and thus a firm association between IgA secretion and BCL-6 expression could not be made.

Gene_expression (expression) of BCL-6 associated with otitis media with effusion

7) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.73 Pain Relevance 0.06

BCL-6 was first discovered as a gene translocated in a type of non-Hodgkin's lymphoma, but it has not been found in terminally differentiated plasma cells.28,29 We found that BCL-6 expression was significantly lower in the OME group, and that it was expressed primarily in the germinal centers.

Gene_expression (expression) of BCL-6 in plasma cells associated with lymphatic system cancer and otitis media with effusion

8) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.58 Pain Relevance 0.05

These results suggest that increased squamous metaplasia and lower BCL-6 expression in adenoids may be associated with increased susceptibility to OME.

Gene_expression (expression) of BCL-6 associated with metaplasia

9) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628093 Disease Relevance 0.60 Pain Relevance 0

To determine the factors associated with OME in children, we evaluated adenoid size, mucosal barrier, squamous changes in ciliated epithelium, IgA secretion, and expression of B cell leukemia lymphoma-6 (BCL-6) in children with and without OME.

Gene_expression (expression) of BCL-6 in B cell associated with lymphatic system cancer, b-cell acute lymphoblastic leukemia and otitis media with effusion

10) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 1.74 Pain Relevance 0.12

One explanation might be that BCL-6 suppresses conversion of B lymphocytes to plasma cells in normal adenoids, but decreased BCL-6 expression during infection allows increased conversion to plasma cells and thus greater production of immunoglobulin.

Gene_expression (expression) of BCL-6 in plasma cells associated with infection

11) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.57 Pain Relevance 0.04

To determine the factors associated with this condition, we evaluated adenoid size, mucosal barrier, squamous changes of ciliated epithelium, IgA secretion, and BCL-6 expression in adenoids.

Gene_expression (expression) of BCL-6 in epithelium

12) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628093 Disease Relevance 0.56 Pain Relevance 0

The OME group showed greater incidence of squamous metaplasia, fewer ciliated cells, and lower expression of BCL-6 (p < 0.05 each).

Gene_expression (expression) of BCL-6 in ciliated cells associated with metaplasia

13) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628093 Disease Relevance 0.56 Pain Relevance 0

The adenoids were also stained with cytokeratin to evaluate mucosal barriers, and with anti-IgA antibody and anti- BCL-6 antibody to determine expression of IgA and BCL-6.

Spec (determine) Gene_expression (expression) of BCL-6

14) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628093 Disease Relevance 0.57 Pain Relevance 0

corepressors, such as B-cell lymphoma 6 (BCL-6), silencing mediator for

Gene_expression (corepressors) of BCL-6 in B-cell associated with lymphatic system cancer

15) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.39 Pain Relevance 0.10

BCL-6 is overexpressed in 40% of diffuse large B-cell lymphomas (Pasqualucci et al. 2003).

Gene_expression (overexpressed) of BCL-6 in B-cell associated with lymphatic system cancer

16) Confidence 0.06 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.08 Pain Relevance 0

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