INT236713

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 27.40 Quite Low
cINOD 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 81 88.56 High High
Targeted Disruption 11 80.48 Quite High
Infection 25 78.64 Quite High
Apoptosis 69 77.20 Quite High
Repression 4 67.92 Quite High
Cancer 109 66.96 Quite High
Death 10 43.52 Quite Low
Obesity 7 7.60 Low Low
Colon Cancer 23 5.00 Very Low Very Low Very Low
Polyps 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDK2, CDK4, and CDK6 are the active kinases controlling G1/S transition in mammals.
Regulation (controlling) of CDK4
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
However, the expressions of various genes involved in cell cycle regulation

(PCNA, c-myc, CDK1, CDK4, and

Regulation (regulation) of CDK4
2) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.33 Pain Relevance 0
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
Neg (not) Regulation (affected) of cdk4
3) Confidence 0.05 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.03 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox