INT236783

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.17
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, TLR4) cytosol (IRF6) signal transduction (TLR4)
plasma membrane (TLR4) intracellular (TLR4) nucleus (IRF6)
IRF6 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 31 99.76 Very High Very High Very High
rheumatoid arthritis 55 95.76 Very High Very High Very High
Inflammation 15 60.16 Quite High
Arthritis 4 56.32 Quite High
agonist 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 34 99.84 Very High Very High Very High
Rheumatoid Arthritis 56 95.76 Very High Very High Very High
INFLAMMATION 18 60.16 Quite High
Disease 7 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Hypercalcemia 1 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Acute-phase Reaction 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 and TLR4 gene expressions decreased in response to cytokine mix, while LPS enhanced TLR2 expression in HC and depressed TLR4 expression in OA patients.
LPS Negative_regulation (depressed) of Gene_expression (expression) of TLR4 associated with osteoarthritis and cytokine
1) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Abstract Doc Link PMC2435281 Disease Relevance 1.17 Pain Relevance 0.57

General Comments

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