INT236786

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 96.28 Very High Very High Very High
rheumatoid arthritis 55 96.08 Very High Very High Very High
cytokine 34 95.76 Very High Very High Very High
Arthritis 4 72.40 Quite High
Inflammatory response 3 57.72 Quite High
agonist 7 47.76 Quite Low
Inflammatory mediators 1 42.24 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 8 98.80 Very High Very High Very High
Osteoarthritis 34 97.88 Very High Very High Very High
INFLAMMATION 21 96.28 Very High Very High Very High
Rheumatoid Arthritis 56 96.08 Very High Very High Very High
Cancer 5 88.32 High High
Necrosis 3 87.84 High High
Arthritis 6 72.40 Quite High
Disease 13 58.88 Quite High
Keratosis 10 53.76 Quite High
Basal Cell Carcinoma 8 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It induces, through stimulation of Toll-like receptors (TLRs) localized on the surface of antigen-presenting cells, synthesis and release of several endogenous pro-inflammatory cytokines such as interferon-?
Positive_regulation (stimulation) of Localization (localized) of Toll associated with inflammation and cytokine
1) Confidence 0.45 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2503670 Disease Relevance 0.59 Pain Relevance 0.10
healthy controls could be explained by increased expression of TLR4 receptors
Positive_regulation (increased) of Localization (receptors) of TLR4
2) Confidence 0.35 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.30 Pain Relevance 0.48

General Comments

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