INT236824

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.30
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (PTH1R) plasma membrane (PTH1R) nucleus (PTH1R)
intracellular (PTH1R) cytoplasm (PTH1R) signal transducer activity (PTH1R)
Anatomy Link Frequency
chondrocytes 8
osteoblasts 8
hyaline cartilage 2
PTH1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 564 100.00 Very High Very High Very High
Arthritis 17 94.44 High High
Pain 3 93.92 High High
Inflammation 38 93.56 High High
metalloproteinase 15 93.20 High High
aspirin 1 56.00 Quite High
cytokine 12 50.84 Quite High
COX2 2 50.00 Quite Low
rheumatoid arthritis 5 20.84 Low Low
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 655 100.00 Very High Very High Very High
Disease 46 99.44 Very High Very High Very High
Arthritis 20 94.44 High High
Pain 2 93.92 High High
INFLAMMATION 44 93.56 High High
Osteophyte 45 86.36 High High
Sclerosis 9 86.28 High High
Stress 11 77.84 Quite High
Hypertrophy 19 77.12 Quite High
Joint Instability 18 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study to determine the influence of osteoarthritic phenotype of subchondral osteoblasts on the phenotype of human chondrocytes demonstrated that sclerotic osteoblasts, but not nonsclerotic osteoblasts induced a significant decrease of PTH1R gene expression in chondrocytes [25].
Negative_regulation (decrease) of Gene_expression (expression) of PTH1R gene in osteoblasts associated with osteoarthritis
1) Confidence 0.58 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.98 Pain Relevance 0.34
Whereas the role of PTH1R in osteoarthritic chondrocytes remains largely unanswered, it was shown that as disease severity in OA progresses, PTH1R expression and protein levels are reduced in human subchondral osteoblasts [11].
Negative_regulation (reduced) of Gene_expression (expression) of PTH1R in osteoblasts associated with disease and osteoarthritis
2) Confidence 0.58 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.38 Pain Relevance 0.39
In summary, the present study shows a decrease in the expression of the PTH1R receptor over the time course of OA.
Negative_regulation (decrease) of Gene_expression (expression) of PTH1R receptor associated with osteoarthritis
3) Confidence 0.58 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.70 Pain Relevance 0.29
This is consistent with findings that as disease severity in OA progresses, PTH1R expression and protein levels are reduced in human subchondral osteoblasts.
Negative_regulation (reduced) of Gene_expression (expression) of PTH1R in osteoblasts associated with disease and osteoarthritis
4) Confidence 0.58 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.09 Pain Relevance 0.35
The results show an in vivo decrease in the expression of PTH1R on chondrocytes over the time course of OA.
Negative_regulation (decrease) of Gene_expression (expression) of PTH1R in chondrocytes associated with osteoarthritis
5) Confidence 0.43 Published 2010 Journal J Orthop Surg Res Section Abstract Doc Link PMC2867974 Disease Relevance 0.56 Pain Relevance 0.21
In contrast, PTH1R gene expression was depressed in sclerotic osteoblasts [24].
Negative_regulation (depressed) of Gene_expression (expression) of PTH1R gene in osteoblasts
6) Confidence 0.42 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.03 Pain Relevance 0.34
We could demonstrate a negative linear correlation between PTH1R expression and macroscopic and histologic grades in the early course of OA.
Negative_regulation (correlation) of Gene_expression (expression) of PTH1R associated with osteoarthritis
7) Confidence 0.42 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.04 Pain Relevance 0.34
The present study was designed to evaluate the expression of the PTH1R on chondrocytes over the time course of experimentally induced secondary OA in an animal model as well as possible correlations between macroscopic and histologic findings in the degenerated hyaline cartilage.


Spec (possible) Negative_regulation (evaluate) of Gene_expression (expression) of PTH1R in hyaline cartilage associated with osteoarthritis
8) Confidence 0.42 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.02 Pain Relevance 0.37
Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis

Background

Negative_regulation (Decrease) of Gene_expression (expression) of PTH/PTHrP in chondrocytes associated with osteoarthritis
9) Confidence 0.37 Published 2010 Journal J Orthop Surg Res Section Title Doc Link PMC2867974 Disease Relevance 0.60 Pain Relevance 0.21
Consistent with this notion, our published study is noteworthy where we showed for the first time that a standardized PFE preparation was non-toxic to human OA chondrocytes and prevented the IL-1?
Negative_regulation (prevented) of Gene_expression (preparation) of PFE in chondrocytes associated with osteoarthritis
10) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.91 Pain Relevance 0.53
In some cases, viability of chondrocytes after exposure to PFE and IL-1?
Negative_regulation (viability) of Gene_expression (exposure) of PFE in chondrocytes
11) Confidence 0.13 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2438359 Disease Relevance 0 Pain Relevance 0.03

General Comments

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