INT236835

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CISH) extracellular space (CSF2) extracellular region (CSF2)
intracellular (CISH) molecular_function (CISH) cellular_component (CISH)
Anatomy Link Frequency
plasma 1
mature B cells 1
CISH (Homo sapiens)
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 28 100.00 Very High Very High Very High
metalloproteinase 52 99.36 Very High Very High Very High
Multiple sclerosis 80 85.76 High High
imagery 38 80.20 Quite High
Central nervous system 26 57.00 Quite High
Inflammation 54 56.24 Quite High
chemokine 6 47.84 Quite Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 40 100.00 Very High Very High Very High
Demyelinating Disease 90 85.76 High High
Recurrence 10 78.68 Quite High
Central Nervous System Disease 26 57.00 Quite High
INFLAMMATION 46 56.24 Quite High
Encephalitis 12 50.00 Quite Low
Neurological Disease 32 5.00 Very Low Very Low Very Low
Lumbar Puncture Related Headaches 12 5.00 Very Low Very Low Very Low
Syndrome 10 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion the results of our study reveal an accumulation of mature B cells and plasma blasts in the CSF of patients with a CIS and RRMS, which is associated with an increased intrathecal CSF cell count and MMP-9, CxCL-13, IgG and IgM synthesis.
CIS Binding (associated) of CSF in mature B cells associated with metalloproteinase, disease and intrathecal
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.72 Pain Relevance 0.63
In conclusion the results of our study reveal an accumulation of mature B cells and plasma blasts in the CSF of patients with a CIS and RRMS, which is associated with an increased intrathecal CSF cell count and MMP-9, CxCL-13, IgG and IgM synthesis.
CIS Binding (associated) of CSF in plasma associated with metalloproteinase, disease and intrathecal
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.72 Pain Relevance 0.63

General Comments

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