INT236839

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 19.27
Pain Relevance 5.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
cell-cell signaling (CXCL13)
Anatomy Link Frequency
B cell 8
CSF 1
MALT 1
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 432 99.74 Very High Very High Very High
Inflammation 181 99.60 Very High Very High Very High
imagery 236 98.28 Very High Very High Very High
chemokine 49 97.84 Very High Very High Very High
Nerve growth factor 8 97.28 Very High Very High Very High
intrathecal 146 97.20 Very High Very High Very High
Central nervous system 55 91.20 High High
cytokine 22 87.44 High High
metalloproteinase 105 68.88 Quite High
rheumatoid arthritis 1 62.84 Quite High
Disease Link Frequency Relevance Heat
Syndrome 634 99.84 Very High Very High Very High
Sialadenitis 3 99.84 Very High Very High Very High
Demyelinating Disease 452 99.74 Very High Very High Very High
Infection 44 99.70 Very High Very High Very High
INFLAMMATION 165 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 89 99.50 Very High Very High Very High
Malignant Neoplastic Disease 8 99.08 Very High Very High Very High
Disease 184 99.02 Very High Very High Very High
Lyme Neuroborreliosis 54 98.40 Very High Very High Very High
Viral Meningitis 18 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, in a recent study a strong correlation between CxCL-13 levels and inflammatory activity in MS was observed, which was reflected by an upregulation of CxCL-13 in actively demyelinating MS lesions and increased CxCL-13 in the CSF [28].
Positive_regulation (upregulation) of CxCL-13 associated with multiple sclerosis, inflammation and demyelinating disease
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 1.11 Pain Relevance 0.44
Further, in a recent study a strong correlation between CxCL-13 levels and inflammatory activity in MS was observed, which was reflected by an upregulation of CxCL-13 in actively demyelinating MS lesions and increased CxCL-13 in the CSF [28].
Positive_regulation (increased) of CxCL-13 associated with multiple sclerosis, inflammation and demyelinating disease
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 1.06 Pain Relevance 0.47
Our observation of elevated CSF CXCL13 in CIS patients with presence of OCB and positive MRZR (Figure 2) demonstrates the association of CXCL13 with the polyspecific intrathecal B cell response in MS, which was suggested to derive from long-lived plasma cells in an enhanced B cell-promoting environment [7].
Positive_regulation (elevated) of CXCL13 in B cell associated with multiple sclerosis, syndrome and intrathecal
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.18 Pain Relevance 0.64
Despite the difference seen in the frequency of CSF B cells between RRMS and CPMS, humoral factors like IgM, IgG and CxCL-13 were found at increased levels in all MS subgroups thus raising the question on their source.
Positive_regulation (increased) of CxCL-13 in B cells associated with multiple sclerosis
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.91 Pain Relevance 0.39
From Table 1 it is evident that CSF, but not serum, CxCL-13 levels were significantly increased in CIS, RRMS and CPMS.
Positive_regulation (increased) of CxCL-13
5) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.32 Pain Relevance 0.38
CXCL13 is no disease-specific marker of MS or CIS: Particularly high concentrations of CSF CXCL13 can be found in patients with neuroborreliosis, which is the neuroinflammatory disease with the highest proportion of B cells in the CSF [24], [35].
Positive_regulation (concentrations) of CXCL13 in B cells associated with multiple sclerosis, syndrome and disease
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.50 Pain Relevance 0.42
Our observation of elevated CSF CXCL13 in CIS patients with presence of OCB and positive MRZR (Figure 2) demonstrates the association of CXCL13 with the polyspecific intrathecal B cell response in MS, which was suggested to derive from long-lived plasma cells in an enhanced B cell-promoting environment [7].
Positive_regulation (observation) of CXCL13 in B cell associated with multiple sclerosis, syndrome and intrathecal
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.19 Pain Relevance 0.64
Our observation of elevated CSF CXCL13 in CIS is in line with previous studies that found CXCL13 to be elevated in CSF and serum across different subtypes of MS as well as in CIS [11], [12], [27], [28].
Positive_regulation (elevated) of CXCL13 associated with multiple sclerosis and syndrome
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.36 Pain Relevance 0.37
Furthermore, CSF CXCL13 was found to be elevated in other inflammatory CNS diseases including viral meningitis and encephalitis [12], confirming its role as a suitable marker of B cell recruitment.
Positive_regulation (elevated) of CXCL13 in B cell associated with inflammation, viral meningitis and disease
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.58 Pain Relevance 0.45
Our observation of elevated CSF CXCL13 in CIS is in line with previous studies that found CXCL13 to be elevated in CSF and serum across different subtypes of MS as well as in CIS [11], [12], [27], [28].
Positive_regulation (elevated) of CXCL13 associated with multiple sclerosis and syndrome
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.35 Pain Relevance 0.38
Consequently, the elevation of B cell-associated markers like CXCL13 in the CSF of patients with CIS could indicate a pro-inflammatory, B cell promoting environment as well as an upregulation of compensatory protective mechanisms [7].
Positive_regulation (elevation) of CXCL13 in B cell associated with inflammation and syndrome
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.13 Pain Relevance 0.55
CSF CXCL13 was significantly elevated in CIS-RRMS as compared to CIS-CIS and controls (p<0.001).
Positive_regulation (elevated) of CXCL13 in CSF associated with syndrome
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2916843 Disease Relevance 1.79 Pain Relevance 0.43
Accordingly, CXCL13 and CCL21 transcript levels were significantly increased in LESA samples while CXCL12 levels were increased in MALT lymphoma and isolated tumor cells.
Positive_regulation (increased) of CXCL13 in MALT associated with lymphatic system cancer, cancer and sialadenitis
13) Confidence 0.22 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.92 Pain Relevance 0.15
In recent studies the importance of CXCL13 in B-cell recruitment in patients with LNB has been suggested [9].
Positive_regulation (importance) of CXCL13 in B-cell associated with lyme neuroborreliosis
14) Confidence 0.11 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3009961 Disease Relevance 1.35 Pain Relevance 0.06
In HIV infection the levels of CXCL13 in serum are elevated and the receptor CXCR5 on B-cells is down regulated causing impaired trafficking of B-cells [10].
Positive_regulation (elevated) of CXCL13 in B-cells associated with acquired immune deficiency syndrome or hiv infection and infection
15) Confidence 0.11 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3009961 Disease Relevance 1.51 Pain Relevance 0.04

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