INT236841

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.17
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
cell-cell signaling (CXCL13)
Anatomy Link Frequency
B-cell 2
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 26 100.00 Very High Very High Very High
Multiple sclerosis 74 98.00 Very High Very High Very High
imagery 39 92.80 High High
chemokine 8 76.32 Quite High
Inflammation 43 50.00 Quite Low
intrathecal 24 14.16 Low Low
Central nervous system 13 5.28 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 81 98.84 Very High Very High Very High
Demyelinating Disease 79 98.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 96.52 Very High Very High Very High
Neurological Disease 16 89.44 High High
Hypergammaglobulinemia 1 83.36 Quite High
Lumbar Puncture Related Headaches 8 80.32 Quite High
Infection 46 79.56 Quite High
Hypersensitivity 4 73.16 Quite High
Hyperplasia 2 61.28 Quite High
Disease 31 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to correct for a passive transfer of MMP-9 and CxCL-13 we calculated a ratio using the following formula: MMP-9 ratio?
Negative_regulation (passive) of Gene_expression (transfer) of CxCL-13 associated with metalloproteinase
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.40 Pain Relevance 0.58
More recently, Cagigi et al have shown that the decrease in CXCR5 expression is concomitant to abnormal CXCL13 production by peripheral and lymph node B-cells and increased B-cell responsiveness to CXCL13 in HIV-1 infected patients with low CD4+ T-cells counts [9].
Negative_regulation (abnormal) of Gene_expression (production) of CXCL13 in B-cell associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.82 Pain Relevance 0.04
We observed a considerable overlap regarding CSF CXCL13 concentrations between the groups as well as a considerable overlap in confidence intervals for the predictive values.
Negative_regulation (overlap) of Gene_expression (concentrations) of CXCL13
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 0.95 Pain Relevance 0.21

General Comments

This test has worked.

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