INT236842

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.91
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
cell-cell signaling (CXCL13)
Anatomy Link Frequency
mature B cells 3
B-cells 2
plasma 1
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 130 100.00 Very High Very High Very High
intrathecal 75 100.00 Very High Very High Very High
imagery 95 92.80 High High
Multiple sclerosis 200 91.44 High High
Inflammation 135 84.08 Quite High
Central nervous system 66 64.84 Quite High
chemokine 15 46.16 Quite Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Migraine 5 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 18 99.90 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 37 99.70 Very High Very High Very High
Disease 105 99.22 Very High Very High Very High
Lyme Neuroborreliosis 27 98.16 Very High Very High Very High
Demyelinating Disease 225 91.44 High High
Neurological Disease 80 89.44 High High
Immunodeficiency 1 84.40 Quite High
INFLAMMATION 115 84.08 Quite High
Lumbar Puncture Related Headaches 31 80.32 Quite High
Recurrence 25 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion the results of our study reveal an accumulation of mature B cells and plasma blasts in the CSF of patients with a CIS and RRMS, which is associated with an increased intrathecal CSF cell count and MMP-9, CxCL-13, IgG and IgM synthesis.
Positive_regulation (increased) of Gene_expression (synthesis) of CxCL-13 in mature B cells associated with metalloproteinase, disease and intrathecal
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.67 Pain Relevance 0.60
In order to correct for a passive transfer of MMP-9 and CxCL-13 we calculated a ratio using the following formula: MMP-9 ratio?
Positive_regulation (transfer) of Gene_expression (transfer) of CxCL-13 associated with metalloproteinase
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.40 Pain Relevance 0.58
Further, CSF and serum CxCL-13 levels of patients with CIS, RRMS and CPMS had similar ranges and also CSF?
Positive_regulation (serum) of Gene_expression (levels) of CxCL-13
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.32 Pain Relevance 0.35
From Table 1 it is evident that CSF, but not serum, CxCL-13 levels were significantly increased in CIS, RRMS and CPMS.
Positive_regulation (increased) of Gene_expression (levels) of CxCL-13
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.32 Pain Relevance 0.38
In conclusion the results of our study reveal an accumulation of mature B cells and plasma blasts in the CSF of patients with a CIS and RRMS, which is associated with an increased intrathecal CSF cell count and MMP-9, CxCL-13, IgG and IgM synthesis.
Positive_regulation (increased) of in plasma Gene_expression (synthesis) of CxCL-13 in mature B cells associated with metalloproteinase, disease and intrathecal
5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.67 Pain Relevance 0.60
In HIV infection the levels of CXCL13 in serum are elevated and the receptor CXCR5 on B-cells is down regulated causing impaired trafficking of B-cells [10].
Positive_regulation (elevated) of Gene_expression (levels) of CXCL13 in B-cells associated with acquired immune deficiency syndrome or hiv infection and infection
6) Confidence 0.11 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3009961 Disease Relevance 1.52 Pain Relevance 0.04

General Comments

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