INT236865

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 18.45
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (AURKC) cytoskeleton (AURKC) nucleus (AURKC)
cell cycle (AURKC) cytoplasm (AURKC)
Anatomy Link Frequency
arm 1
AURKC (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 9 98.32 Very High Very High Very High
analgesia 9 97.36 Very High Very High Very High
Pain 29 94.64 High High
Inflammation 99 89.20 High High
imagery 1 88.88 High High
cytokine 9 44.04 Quite Low
Prostatitis 9 31.52 Quite Low
colic 9 20.80 Low Low
cINOD 63 5.00 Very Low Very Low Very Low
antagonist 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 1546 100.00 Very High Very High Very High
Lower Urinary Tract Symptoms 202 100.00 Very High Very High Very High
Diuresis 40 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 671 99.84 Very High Very High Very High
Infarction 72 99.00 Very High Very High Very High
Recurrence 9 96.08 Very High Very High Very High
Pain 19 94.64 High High
Constipation 54 93.00 High High
INFLAMMATION 108 89.20 High High
Disease Progression 16 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The slight decrease in the incidence of primary AUR suggests that the shift away from surgical treatment of BPH has not resulted in an increase in the AUR.
Positive_regulation (increase) of AUR associated with benign prostatic hypertrophy and overactive bladder
1) Confidence 0.57 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.02 Pain Relevance 0
The increase in recurrent AUR suggests that the observed decrease in surgery after AUR might have put more men at risk for AUR recurrence.[8]

NATURAL HISTORY OF AUR

Positive_regulation (increase) of AUR associated with overactive bladder and recurrence
2) Confidence 0.57 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.04 Pain Relevance 0
This trend coincided with a 20% increase in the rate of recurrent AUR.
Positive_regulation (increase) of AUR associated with overactive bladder
3) Confidence 0.57 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.04 Pain Relevance 0
Kim CI et al., from a retrospective analysis of 341 patients (192 patients in alpha blocker only group, 149 patients in combination treatment, followed up for six to eight years) reported the incidence of AUR in BPH patients receiving alpha blockers alone and combination of alpha blocker and a-alpha- reductase inhibitor.
Positive_regulation (incidence) of AUR associated with benign prostatic hypertrophy and overactive bladder
4) Confidence 0.41 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 0.86 Pain Relevance 0
In the alpha blocker group 17.7% patients and 12.1% in the combination group experienced AUR (P < 0.05).[33]

Surgical management

Positive_regulation (experienced) of AUR associated with overactive bladder
5) Confidence 0.41 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 0.95 Pain Relevance 0
Postoperative AUR
Positive_regulation (Postoperative) of AUR associated with overactive bladder
6) Confidence 0.41 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.44 Pain Relevance 0.29
Anticholinergics can be safely combined with alpha blockers in symptomatic BPH patients without increasing the risk of AUR.
Neg (without) Positive_regulation (increasing) of AUR associated with benign prostatic hypertrophy and overactive bladder
7) Confidence 0.41 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Abstract Doc Link PMC2721562 Disease Relevance 1.59 Pain Relevance 0
The precise mechanism which precipitates AUR in BPH has not been fully described.
Positive_regulation (precipitates) of AUR associated with benign prostatic hypertrophy and overactive bladder
8) Confidence 0.38 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.21
Differential epithelial/stromal growth may predispose to infarction through effects on the vascular supply which may result in AUR.
Positive_regulation (result) of AUR associated with overactive bladder and infarction
9) Confidence 0.38 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.45 Pain Relevance 0
However, extensive data from the placebo arm of the Proscar Long-term Efficacy and Safety Study (PLESS) have demonstrated that PSA is a strong predictor of an enlarged prostate, or one that is likely to increase in size, as well as the risk of developing LUTS, poor urinary flow, AUR and/or BPH-related surgery (19).
Positive_regulation (increase) of AUR in arm associated with diuresis, benign prostatic hypertrophy, overactive bladder and lower urinary tract symptoms
10) Confidence 0.17 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2440415 Disease Relevance 0.92 Pain Relevance 0.04
However, men with a stable or worsening IPSS at 6 months of treatment had a significantly increased risk for AUR (hazard ratio [HR] 3.75, 95% CI 1.58–8.89) and BPH-related surgery (HR 4.71, 95% CI 2.69–8.24); those with an IPSS bother score of >3 during treatment also had a significantly increased risk for BPH-related surgery (HR 7.61, 95% CI 4.16–13.93) (Emberton et al 2006).
Positive_regulation (increased) of AUR associated with benign prostatic hypertrophy
11) Confidence 0.02 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682383 Disease Relevance 1.03 Pain Relevance 0

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