INT236867

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 20
Disease Relevance 31.96
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (AURKC) cytoskeleton (AURKC) nucleus (AURKC)
cell cycle (AURKC) cytoplasm (AURKC)
Anatomy Link Frequency
bowel 1
glands 1
AURKC (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 51 97.84 Very High Very High Very High
agonist 32 95.20 Very High Very High Very High
Onset of action 13 89.84 High High
Pain 50 89.52 High High
Inflammation 165 89.20 High High
analgesia 15 88.36 High High
anesthesia 15 87.92 High High
Central nervous system 7 87.84 High High
cva 45 86.48 High High
alcohol 45 85.76 High High
Disease Link Frequency Relevance Heat
Overactive Bladder 2634 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 1277 100.00 Very High Very High Very High
Constipation 90 100.00 Very High Very High Very High
Urinary Tract Infection 163 99.88 Very High Very High Very High
Lower Urinary Tract Symptoms 405 99.08 Very High Very High Very High
Bacteremia 15 99.04 Very High Very High Very High
Fever 15 97.48 Very High Very High Very High
Hypertension 38 97.16 Very High Very High Very High
Recurrence 15 96.08 Very High Very High Very High
Neurological Disease 15 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in recurrent AUR suggests that the observed decrease in surgery after AUR might have put more men at risk for AUR recurrence.[8]

NATURAL HISTORY OF AUR

Gene_expression (recurrent) of AUR associated with overactive bladder and recurrence
1) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.03 Pain Relevance 0
The precise mechanism which precipitates AUR in BPH has not been fully described.
Gene_expression (precipitates) of AUR associated with benign prostatic hypertrophy and overactive bladder
2) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.21
Postoperative AUR occurs whether or not BPH is present.[17]

Genitourinary instrumentation

Gene_expression (Postoperative) of AUR associated with benign prostatic hypertrophy and overactive bladder
3) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.42 Pain Relevance 0.27
In the Alfuzosin in Acute Urinary Retention (ALFAUR) study a careful history of bowel habits was taken from 363 men presenting with AUR related to BPH.
Gene_expression (presenting) of AUR in bowel associated with benign prostatic hypertrophy and overactive bladder
4) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.50 Pain Relevance 0.20
Medications and AUR
Gene_expression (Medications) of AUR associated with overactive bladder
5) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.67 Pain Relevance 0.41
Most men presenting with AUR were hospitalized in France (69%) and Russia (80%), whereas few were admitted to the hospital in Mexico (22%), Denmark (25%) or the Netherlands (27%).[4] In the recent UK survey on the management of AUR, most urologists (65.5%) preferred to admit their patients after catheterization, while a further 19.3% would admit only if renal function was impaired.
Gene_expression (presenting) of AUR associated with overactive bladder
6) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 0.79 Pain Relevance 0
Consequently, spontaneous and precipitated AUR may be considered to be the same when they are BPH-related, as the approach to initial management need not be altered.[23]

MANAGEMENT OF AUR IN BPH

Gene_expression (spontaneous) of AUR associated with benign prostatic hypertrophy and overactive bladder
7) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.54 Pain Relevance 0
Postoperative AUR occurs whether or not BPH is present.[17]

Genitourinary instrumentation

Neg (not) Spec (whether) Gene_expression (occurs) of AUR associated with benign prostatic hypertrophy and overactive bladder
8) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.41 Pain Relevance 0.26
It has also been found that immediate prostate surgery is associated with increased perioperative complications than delayed surgery in patients presenting with AUR.
Gene_expression (presenting) of AUR associated with overactive bladder
9) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.25 Pain Relevance 0
Emberton M et al. analyzed data from 5,792 men with BPH-related symptoms on medical management and reported that prior AUR is a strong predictor of recurrent AUR with a hazard ratio of 3.75% (95% CI 1.58 to 8.89).[11]

ETIOPATHOGENESIS

Gene_expression (prior) of AUR associated with benign prostatic hypertrophy and overactive bladder
10) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.94 Pain Relevance 0.06
‘PRECIPITATED” AUR
Gene_expression (PRECIPITATED) of AUR associated with overactive bladder
11) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.64 Pain Relevance 0.36
Constipation and AUR
Gene_expression (Constipation) of AUR associated with constipation and overactive bladder
12) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.49 Pain Relevance 0
Hence in BPH patients presenting with AUR, it is essential to delay the surgical treatment by initially offering TWOC following the use of alpha blockers.


Gene_expression (presenting) of AUR associated with benign prostatic hypertrophy and overactive bladder
13) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.28 Pain Relevance 0
After controlling for background covariates, dutasteride-treated patients were 49.1% less likely to experience AUR than patients treated with finasteride (P=.0207).
Gene_expression (experience) of AUR associated with overactive bladder
14) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.11 Pain Relevance 0
The 1242 patients presenting with AUR were older and had larger glands and more comorbidities.
Gene_expression (presenting) of AUR in glands associated with overactive bladder
15) Confidence 0.55 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.09 Pain Relevance 0
Progression to AUR or BPH-related surgery
Gene_expression (Progression) of AUR associated with benign prostatic hypertrophy and overactive bladder
16) Confidence 0.23 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2440415 Disease Relevance 1.39 Pain Relevance 0
Effects on AUR and BPH-related surgery
Gene_expression (surgery) of AUR associated with benign prostatic hypertrophy and overactive bladder
17) Confidence 0.23 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2440415 Disease Relevance 0.71 Pain Relevance 0
Effects on AUR and BPH-related surgery
Gene_expression (surgery) of AUR associated with benign prostatic hypertrophy and overactive bladder
18) Confidence 0.23 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2440415 Disease Relevance 0.88 Pain Relevance 0.09
4 points, and overall BPH progression [AUR and/or surgery and/or LUTS worsening]) were evaluated in the 2-year, placebo-controlled ALTESS study (Roehrborn 2006a).
Gene_expression (progression) of AUR associated with benign prostatic hypertrophy and lower urinary tract symptoms
19) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682383 Disease Relevance 0.96 Pain Relevance 0
Role in AUR management
Gene_expression (management) of AUR
20) Confidence 0.03 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682383 Disease Relevance 0.75 Pain Relevance 0

General Comments

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