INT236882

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tpo) oxidoreductase activity (Tpo) plasma membrane (Tpo)
cytoplasm (Tpo)
Anatomy Link Frequency
thyroid 2
Tpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 48 99.84 Very High Very High Very High
Necrosis 2 87.62 High High
Hemorrhage 6 87.42 High High
Thyroid Neoplasm 34 64.88 Quite High
Carcinoma 20 62.44 Quite High
Metastasis 2 53.72 Quite High
Lymphatic System Cancer 2 53.16 Quite High
Thyroiditis 2 50.20 Quite High
Adenoma 28 49.20 Quite Low
Hyperthyroidism 12 47.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fine-needle aspiration cytology (FNAC) has been the standard method for differentiating between benign and malignant nodules, but as cystic degeneration, bleeding, necrosis and calcifications are common features of both benign and malignant nodules, routine FNAC is highly person dependent and may carry a low sensitivity and specificity, resulting in a high surgery rate for benign nodules.9–14 Other diagnostic methods have therefore been introduced, including ultrasound-guided FNAC15–17 and ultrasound-guided needle core biopsy (NCB).18–24 The enzyme thyroid peroxidase (TPO) appears to be changed early in malignant transformation, and it has been discussed whether this enzyme might be a marker of benign vs. malignant thyroid lesions.25 The monoclonal antibody 47 (mAb 47) has a high affinity for TPO of normal or benign thyrocytes but a very weak or absent affinity for the TPO of malignant epithelial cells, in particular those from nonfollicular malignancies.26–30
TPO Binding (affinity) of in thyroid associated with necrosis, malignant neoplastic disease and hemorrhage
1) Confidence 0.47 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2440416 Disease Relevance 1.34 Pain Relevance 0
Fine-needle aspiration cytology (FNAC) has been the standard method for differentiating between benign and malignant nodules, but as cystic degeneration, bleeding, necrosis and calcifications are common features of both benign and malignant nodules, routine FNAC is highly person dependent and may carry a low sensitivity and specificity, resulting in a high surgery rate for benign nodules.9–14 Other diagnostic methods have therefore been introduced, including ultrasound-guided FNAC15–17 and ultrasound-guided needle core biopsy (NCB).18–24 The enzyme thyroid peroxidase (TPO) appears to be changed early in malignant transformation, and it has been discussed whether this enzyme might be a marker of benign vs. malignant thyroid lesions.25 The monoclonal antibody 47 (mAb 47) has a high affinity for TPO of normal or benign thyrocytes but a very weak or absent affinity for the TPO of malignant epithelial cells, in particular those from nonfollicular malignancies.26–30
TPO Neg (absent) Binding (affinity) of in thyroid associated with necrosis, malignant neoplastic disease and hemorrhage
2) Confidence 0.32 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2440416 Disease Relevance 1.16 Pain Relevance 0

General Comments

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