INT236884

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tpo) oxidoreductase activity (Tpo) plasma membrane (Tpo)
cytoplasm (Tpo)
Anatomy Link Frequency
thyroid 2
Tpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 30 99.80 Very High Very High Very High
Cancer 15 98.64 Very High Very High Very High
Adenoma 42 95.90 Very High Very High Very High
Thyroid Neoplasm 51 94.40 High High
Malignant Neoplastic Disease 72 89.00 High High
Hyperplasia 3 87.12 High High
Hemorrhage 9 74.76 Quite High
Metaplasia 6 19.00 Low Low
Hyperthyroidism 18 18.16 Low Low
Thyroid Nodule 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although TPO was significantly reduced or negative in all nonfollicular neoplasms, it was not of sufficient discriminatory value in the diagnosis of follicular adenoma vs. carcinoma,30,34 in particular of the oxyphilic type.34 These results have been confirmed by observations on TPO mRNA analyses on 20 thyroid carcinomas,28 and it has further been demonstrated that the reduced TPO antigenicity is due to a quantitative rather than a qualitative loss.29
Negative_regulation (reduced) of TPO in thyroid associated with adenoma, cancer and carcinoma
1) Confidence 0.57 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2440416 Disease Relevance 0.54 Pain Relevance 0
Sensitivity and specificity of this method were found to be 100% and 86·7%, respectively.25–27 In accordance with their findings, we did identify all nonfollicular carcinomas by their lack of TPO immunostaining.
Negative_regulation (lack) of TPO associated with carcinoma
2) Confidence 0.42 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2440416 Disease Relevance 0.78 Pain Relevance 0
Although TPO was significantly reduced or negative in all nonfollicular neoplasms, it was not of sufficient discriminatory value in the diagnosis of follicular adenoma vs. carcinoma,30,34 in particular of the oxyphilic type.34 These results have been confirmed by observations on TPO mRNA analyses on 20 thyroid carcinomas,28 and it has further been demonstrated that the reduced TPO antigenicity is due to a quantitative rather than a qualitative loss.29
Negative_regulation (reduced) of TPO in thyroid associated with adenoma, cancer and carcinoma
3) Confidence 0.42 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2440416 Disease Relevance 0.65 Pain Relevance 0

General Comments

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