INT236916

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.48
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccnd2) nucleolus (Ccnd2) nucleus (Ccnd2)
cell cycle (Ccnd2) cell division (Ccnd2) cytoplasm (Ccnd2)
Anatomy Link Frequency
neuronal precursors 2
skin 1
Ccnd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 97.56 Very High Very High Very High
imagery 3 77.92 Quite High
antagonist 3 46.64 Quite Low
Pyramidal cell 52 35.20 Quite Low
cINOD 6 16.64 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 121 100.00 Very High Very High Very High
Hyperplasia 5 100.00 Very High Very High Very High
Vulvitis 15 99.80 Very High Very High Very High
Targeted Disruption 76 99.24 Very High Very High Very High
Lichen 18 97.88 Very High Very High Very High
Sclerosis 29 97.60 Very High Very High Very High
Myeloid Leukemia 1 96.68 Very High Very High Very High
Leukemia 4 96.48 Very High Very High Very High
Stress 7 88.00 High High
Breast Cancer 5 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absorption and scattering coefficients estimated at these wavelengths determined a sensitivity of the approach of more than 75% for the detection of both VIN and vulvitis cases, and of 66% for the detection of lichen sclerosis.
Gene_expression (detection) of VIN associated with lichen, cancer, sclerosis and vulvitis
1) Confidence 0.46 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994441 Disease Relevance 0.78 Pain Relevance 0.04
The strong expression of cyclinD2, i.e. the only D-type cyclin expressed in dividing cells derived from neuronal precursors in adult hippocampus [35] prompted us to inject cyclinD2 deficient mice intracerebrally with AAV-Tau.P301L.
Gene_expression (expression) of cyclinD2 in neuronal precursors associated with hippocampus
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.21 Pain Relevance 0.05
The strong expression of cyclinD2, i.e. the only D-type cyclin expressed in dividing cells derived from neuronal precursors in adult hippocampus [35] prompted us to inject cyclinD2 deficient mice intracerebrally with AAV-Tau.P301L.
Gene_expression (expressed) of cyclinD2 in neuronal precursors associated with hippocampus
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.21 Pain Relevance 0.05
p27(KIP1) expression and inhibited cyclin E, cyclin D2 and CDK2 [122].
Gene_expression (expression) of cyclin D2
4) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.75 Pain Relevance 0
One of the most affected processes in skin from K14E6 transgenic mice was the cell cycle, which shows overexpression of genes that induced cellular proliferation like cyclins A2, E, D2, B1, B2 and Cdk4 (Figure 4).
Gene_expression (overexpression) of D2 in skin associated with targeted disruption and hyperplasia
5) Confidence 0.04 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.53 Pain Relevance 0

General Comments

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