INT236928

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.49
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Araf) signal transduction (Araf) mitochondrion (Araf)
kinase activity (Araf)
Araf (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 18 81.20 Quite High
antagonist 9 52.08 Quite High
cOX1 6 32.80 Quite Low
COX2 9 15.76 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 210 95.36 Very High Very High Very High
Colon Cancer 12 69.52 Quite High
Myeloid Leukemia 3 67.16 Quite High
Leukemia 9 66.96 Quite High
Peptic Ulcer 3 65.28 Quite High
Reprotox - General 1 3 64.20 Quite High
Solid Tumor 3 61.48 Quite High
Disease 12 59.36 Quite High
Breast Cancer 15 52.08 Quite High
Non-small-cell Lung Cancer 15 42.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
selective Raf inhibitors are under development [148].
Negative_regulation (inhibitors) of Raf
1) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.44 Pain Relevance 0.19
performed using MEK or Raf inhibitors in combination with PPAR?
Negative_regulation (inhibitors) of Raf
2) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.34 Pain Relevance 0.22
downstream ERK cascade, such as Raf and MEK, may constitute a possible new
Negative_regulation (downstream) of Raf
3) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.70 Pain Relevance 0.09

General Comments

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