INT236945

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.98
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl13) extracellular space (Cxcl13) extracellular region (Cxcl13)
cell-cell signaling (Cxcl13)
Anatomy Link Frequency
gut associated lymphoid tissue 2
Cxcl13 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 12 99.36 Very High Very High Very High
rheumatoid arthritis 219 98.48 Very High Very High Very High
Inflammation 56 96.04 Very High Very High Very High
cytokine 6 95.12 Very High Very High Very High
Chronic pancreatitis 37 91.40 High High
Central nervous system 11 78.04 Quite High
Bile 6 8.72 Low Low
fibrosis 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 25 99.52 Very High Very High Very High
Rheumatoid Arthritis 219 98.48 Very High Very High Very High
Syndrome 9 97.20 Very High Very High Very High
Togavirus Infection 75 97.04 Very High Very High Very High
INFLAMMATION 62 96.04 Very High Very High Very High
Graves' Ophthalmopathy 1 95.64 Very High Very High Very High
Disease 60 95.32 Very High Very High Very High
Primary Sclerosing Cholangitis 30 93.60 High High
Inflammatory Bowel Disease 9 92.20 High High
Pancreatitis 54 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL13 and its receptor CXCR5 are involved in the organization and compartmentalization of lymph follicles and are overexpressed in various autoimmune diseases, like rheumatoid arthritis, Sjögren's syndrome, Hashimoto's thyreoiditis and Graves' disease, and in gut associated lymphoid tissue (GALT) of patients affected by ulcerative colitis.[20]–[23] This novel finding provides a further functional link between AIPC and some of the most frequently reported AIPC-associated conditions, such as Sjögren's syndrome and ulcerative colitis and gives further support to the still debated hypothesis of an autoimmune pathogenesis of AIPC.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CXCL13 in gut associated lymphoid tissue associated with inflammatory bowel disease, autoimmune disease, syndrome, graves' ophthalmopathy, rheumatoid arthritis and disease
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.48 Pain Relevance 0.18
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Cxcl13 associated with chemokine
2) Confidence 0.30 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.90 Pain Relevance 0.63
As synovial tissues containing sites of ectopic lymphoneogenesis have been demonstrated to be closely associated with increased expression levels of CXCL13 and LT?
Positive_regulation (increased) of Gene_expression (levels) of CXCL13
3) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.30 Pain Relevance 0.15
As synovial tissues containing sites of ectopic lymphoneogenesis have been demonstrated to be closely associated with increased expression levels of CXCL13 and LT?
Positive_regulation (increased) of Gene_expression (expression) of CXCL13
4) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.30 Pain Relevance 0.15

General Comments

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