INT236951

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2008
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.20
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr5) plasma membrane (Cxcr5) signal transducer activity (Cxcr5)
Anatomy Link Frequency
B-cell 2
follicles 1
gut associated lymphoid tissue 1
Cxcr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 9 100.00 Very High Very High Very High
rheumatoid arthritis 8 98.48 Very High Very High Very High
Chronic pancreatitis 222 95.52 Very High Very High Very High
fibrosis 54 83.52 Quite High
Inflammation 154 83.32 Quite High
Inflammatory response 10 82.56 Quite High
addiction 1 82.12 Quite High
cytokine 27 62.72 Quite High
tolerance 5 10.96 Low Low
Bile 36 7.76 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 180 99.92 Very High Very High Very High
Epstein-barr Virus 7 99.92 Very High Very High Very High
Autoimmune Disease 64 99.52 Very High Very High Very High
Rheumatoid Arthritis 8 98.48 Very High Very High Very High
Syndrome 29 97.20 Very High Very High Very High
Disease 266 95.76 Very High Very High Very High
Graves' Ophthalmopathy 6 95.64 Very High Very High Very High
Pancreatitis 324 95.52 Very High Very High Very High
Repression 9 93.20 High High
Inflammatory Bowel Disease 55 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the expression of CXCL13 (BCA-1, B-cell attracting chemokine 1) and CXCR5 (BLR1, Burkitt lymphoma receptor-1) was examined, aiming at identifying further AIPC-specific tissue markers possibly related to the autoimmune pathogenesis of this disorder.
Spec (examined) Gene_expression (expression) of CXCR5 in B-cell associated with chemokine and epstein-barr virus
1) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.78 Pain Relevance 0.29
CXCL13 and CXCR5 are in fact involved in normal lymphocyte trafficking and homing in secondary lymphoid organs and are highly expressed in various autoimmune diseases characterized by the occurrence of ectopic lymphoid follicles [20]–[23], which are also a prominent feature of AIPC.
Gene_expression (expressed) of CXCR5 in follicles associated with autoimmune disease
2) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.86 Pain Relevance 0.35
CXCL13 and its receptor CXCR5 are involved in the organization and compartmentalization of lymph follicles and are overexpressed in various autoimmune diseases, like rheumatoid arthritis, Sjögren's syndrome, Hashimoto's thyreoiditis and Graves' disease, and in gut associated lymphoid tissue (GALT) of patients affected by ulcerative colitis.[20]–[23] This novel finding provides a further functional link between AIPC and some of the most frequently reported AIPC-associated conditions, such as Sjögren's syndrome and ulcerative colitis and gives further support to the still debated hypothesis of an autoimmune pathogenesis of AIPC.
Gene_expression (overexpressed) of CXCR5 in gut associated lymphoid tissue associated with inflammatory bowel disease, autoimmune disease, syndrome, graves' ophthalmopathy, rheumatoid arthritis and disease
3) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.47 Pain Relevance 0.18
Moreover, the expression of CXCL13 (BCA-1, B-cell attracting chemokine 1) and CXCR5 (BLR1, Burkitt lymphoma receptor-1) was examined, aiming at identifying further AIPC-specific tissue markers possibly related to the autoimmune pathogenesis of this disorder.
Spec (examined) Gene_expression (expression) of BLR1 in B-cell associated with chemokine and epstein-barr virus
4) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.78 Pain Relevance 0.29
CXCR5- and CXCL13-positive cells were almost exclusively detected in AIPC.


Gene_expression (detected) of CXCR5
5) Confidence 0.51 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2440515 Disease Relevance 1.04 Pain Relevance 0.36
To confirm the overexpression of CXCR5 and CXCL13 in AIPC, real-time quantitative PCR was additionally performed.
Gene_expression (overexpression) of CXCR5
6) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.02 Pain Relevance 0.46
Bcl-6 also represses expression of many miRNAs predicted to control the T follicular cell signature, including miR-17-92, which represses CXCR5 expression.
Gene_expression (expression) of CXCR5
7) Confidence 0.32 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox