INT236952

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.28
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sparcl1) extracellular space (Sparcl1) extracellular region (Sparcl1)
proteinaceous extracellular matrix (Sparcl1)
Anatomy Link Frequency
extracellular matrix 4
Sparcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 37 95.28 Very High Very High Very High
fibrosis 25 88.64 High High
cytokine 28 72.40 Quite High
chemokine 11 71.28 Quite High
Inflammation 59 56.32 Quite High
rheumatoid arthritis 1 18.92 Low Low
Bile 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 3 99.84 Very High Very High Very High
Disease 33 98.86 Very High Very High Very High
Malignant Neoplastic Disease 2 98.70 Very High Very High Very High
Pancreatitis 54 95.28 Very High Very High Very High
Cancer 1 91.12 High High
Fibrosis 26 88.64 High High
Primary Sclerosing Cholangitis 30 73.52 Quite High
INFLAMMATION 60 56.32 Quite High
Autoimmune Disease 3 39.48 Quite Low
Inflammatory Bowel Disease 9 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic OVA challenged Siglec-F deficient mice express increased levels of the extracellular matrix protein fibronectin
Positive_regulation (increased) of Gene_expression (express) of extracellular matrix protein in extracellular matrix
1) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.06
Chronic OVA challenge in WT mice induced a significant increase in the area of peribronchial immunostaining of the extracellular matrix protein fibronectin compared to non-OVA challenged mice (p < 0.0001)(Figure 4A).
Positive_regulation (increase) of Gene_expression (immunostaining) of extracellular matrix protein in extracellular matrix
2) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.07
Moreover, the increased expression of collagen V–a collagen type that has been shown to accumulate in malignant disease [40]–and the more diffuse distribution of Tenascin C–an ECM protein that is overexpressed in pancreatic cancer [41]–and of ?
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ECM protein associated with malignant neoplastic disease, pancreatic cancer and disease
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.28 Pain Relevance 0.45

General Comments

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