INT236953

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.73
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sparcl1) extracellular space (Sparcl1) extracellular region (Sparcl1)
proteinaceous extracellular matrix (Sparcl1)
Anatomy Link Frequency
extracellular matrix 4
Sparcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 37 95.28 Very High Very High Very High
fibrosis 41 93.96 High High
cytokine 56 72.40 Quite High
chemokine 21 71.28 Quite High
Inflammation 97 65.08 Quite High
rheumatoid arthritis 1 18.92 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 3 99.84 Very High Very High Very High
Disease 33 98.86 Very High Very High Very High
Malignant Neoplastic Disease 2 98.70 Very High Very High Very High
Pancreatitis 54 95.28 Very High Very High Very High
Fibrosis 44 93.96 High High
Airway Remodeling 104 93.84 High High
Cancer 1 91.12 High High
Asthma 56 74.40 Quite High
Primary Sclerosing Cholangitis 30 73.52 Quite High
INFLAMMATION 100 65.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic OVA challenged Siglec-F deficient mice express increased levels of the extracellular matrix protein fibronectin
Gene_expression (express) of extracellular matrix protein in extracellular matrix
1) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.06
Detection of extracellular matrix protein fibronectin
Gene_expression (Detection) of extracellular matrix protein in extracellular matrix
2) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.09 Pain Relevance 0.13
Chronic OVA challenge in WT mice induced a significant increase in the area of peribronchial immunostaining of the extracellular matrix protein fibronectin compared to non-OVA challenged mice (p < 0.0001)(Figure 4A).
Gene_expression (immunostaining) of extracellular matrix protein in extracellular matrix
3) Confidence 0.12 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.07
1+ cells, and increased levels of expression of the extracellular matrix protein fibronectin compared to OVA challenged WT mice.
Gene_expression (expression) of extracellular matrix protein in extracellular matrix
4) Confidence 0.11 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2988013 Disease Relevance 0.36 Pain Relevance 0.11
Moreover, the increased expression of collagen V–a collagen type that has been shown to accumulate in malignant disease [40]–and the more diffuse distribution of Tenascin C–an ECM protein that is overexpressed in pancreatic cancer [41]–and of ?
Gene_expression (overexpressed) of ECM protein associated with malignant neoplastic disease, pancreatic cancer and disease
5) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.28 Pain Relevance 0.45

General Comments

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