INT236956

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.13
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDZD2) cell adhesion (PDZD2) endoplasmic reticulum (PDZD2)
nucleus (PDZD2) cytoplasm (PDZD2)
Anatomy Link Frequency
liver 2
PDZD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 148 100.00 Very High Very High Very High
Crohn's disease 8 93.44 High High
addiction 5 89.28 High High
Inflammation 89 89.04 High High
alcohol 8 75.32 Quite High
aspirin 52 60.56 Quite High
antagonist 1 50.32 Quite High
fibrosis 36 35.52 Quite Low
Bile 24 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 216 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 120 100.00 Very High Very High Very High
Prostate Cancer 27 100.00 Very High Very High Very High
Disease 141 98.24 Very High Very High Very High
Asthma 91 98.00 Very High Very High Very High
Inflammatory Bowel Disease 36 91.92 High High
INFLAMMATION 87 89.04 High High
Cirrhosis 20 85.64 High High
Hypersensitivity 11 75.68 Quite High
Alcohol Addiction 8 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the intronic rs4867084G>A of the PDZK3 gene (P?
Gene_expression (gene) of PDZK3
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.76 Pain Relevance 0.06
AIPC's increased proliferation and PSA secretion in the absence of androgen suggests a failure in the regulation of androgen receptor activation.
Gene_expression (proliferation) of AIPC associated with prostate cancer
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.34 Pain Relevance 0.07
Collagen I, III, V and VI were all expressed in the AIPC and CP group, although with different patterns and intensities.
Gene_expression (expressed) of AIPC associated with chronic pancreatitis
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.79 Pain Relevance 0.45
80°C for RNA extraction were available from 7 AIPC cases (pancreas), 5 non-autoimmune CP cases (pancreas) and 5 PSC cases (liver).
Gene_expression (cases) of AIPC in liver associated with primary sclerosing cholangitis and chronic pancreatitis
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.59 Pain Relevance 0.38
80°C for RNA extraction were available from 7 AIPC cases (pancreas), 5 non-autoimmune CP cases (pancreas) and 5 PSC cases (liver).
Gene_expression (cases) of AIPC in liver associated with primary sclerosing cholangitis and chronic pancreatitis
5) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.61 Pain Relevance 0.38
To confirm the overexpression of CXCR5 and CXCL13 in AIPC, real-time quantitative PCR was additionally performed.
Gene_expression (overexpression) of AIPC
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.03 Pain Relevance 0.46

General Comments

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