INT236958

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.24
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDZD2) cell adhesion (PDZD2) endoplasmic reticulum (PDZD2)
nucleus (PDZD2) cytoplasm (PDZD2)
Anatomy Link Frequency
plasma cells 1
biliary tract 1
PDZD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 148 99.48 Very High Very High Very High
fibrosis 36 81.28 Quite High
Inflammation 84 77.28 Quite High
rheumatoid arthritis 4 41.52 Quite Low
Bile 24 38.92 Quite Low
alcohol 8 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 120 99.76 Very High Very High Very High
Pancreatitis 216 99.48 Very High Very High Very High
Inflammatory Bowel Disease 36 99.00 Very High Very High Very High
Disease 132 97.68 Very High Very High Very High
Biliary Tract Disease 4 94.98 High High
Cirrhosis 20 88.28 High High
Fibrosis 32 81.28 Quite High
INFLAMMATION 80 77.28 Quite High
Obesity 4 69.16 Quite High
Malignant Neoplastic Disease 8 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since the IgG4/plasma cell ratio was not different between groups, the observed increase of IgG4-positive cells in AIPC appears to be simply due to an increase in the total number of infiltrating plasma cells.
Positive_regulation (increase) of AIPC in plasma cells
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.01 Pain Relevance 0.26
More appropriately, this entity has been recently defined as autoimmune pancreatocholangitis (AIPC). [5] The AIPC-concept, which has been first suggested by Zen et al.,[36] relies on the embryological and morphological similarities between the ductal system of the pancreas and the biliary tract, and is also supported by the results of the present study, which demonstrate that the biliary tract involvement shares morphological and immunological characteristics with the pancreatic involvement itself and differs clearly from other biliary tract diseases, such as PSC.[37] Clinical aspects, such as patients' age (significantly higher in AIPC patients with extrapancreatic biliary involvement) and the consistent association of PSC with ulcerative colitis appeared to be of further help in distinguishing extrapancreatic AIPC from PSC.
Positive_regulation (extrapancreatic) of AIPC in biliary tract associated with inflammatory bowel disease, primary sclerosing cholangitis and biliary tract disease
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.04 Pain Relevance 0.10
Median CXCR5-mRNA levels in AIPC showed a 4.1-fold increase in comparison with CP (p?
Positive_regulation (increase) of AIPC associated with chronic pancreatitis
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.08 Pain Relevance 0.49
In detail, Tenascin C m-RNA levels displayed a 5.5-fold increase in AIPC compared to CP (p?
Positive_regulation (increase) of AIPC associated with chronic pancreatitis
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.11 Pain Relevance 0.32

General Comments

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