INT236980

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.43
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ISCA1) structural molecule activity (ISCA1)
ISCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 97.76 Very High Very High Very High
Pain 50 81.44 Quite High
Potency 16 48.08 Quite Low
headache 56 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 136 99.60 Very High Very High Very High
INFLAMMATION 32 97.76 Very High Very High Very High
Panniculitis 16 96.72 Very High Very High Very High
Hypersensitivity 16 93.00 High High
Disease 59 92.00 High High
Infection 32 91.12 High High
Sarcoidosis 8 89.60 High High
Pressure And Volume Under Development 49 89.36 High High
Mycobacterial Infection 8 88.40 High High
Malaria 144 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isu1, its homologue Isu2, Nfu, Isa1, and Isa2 are all proposed to function as scaffold proteins upon which Fe?
Gene_expression (proposed) of Isa1
1) Confidence 0.53 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0 Pain Relevance 0
Due to Pfs25's poor immunogenicity and inadequate binding to Alhydrogel, a different adjuvant platform using Montanide ISA 51 was explored for its further clinical development
Gene_expression (using) of ISA
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0.48 Pain Relevance 0.08
Ten volunteers in each of the 5 µg Pvs25/ISA 51, 20 µg Pvs25/ISA 51, and 5 µg Pfs25/ISA 51 dose groups were enrolled and received their first vaccinations.
Gene_expression (/) of ISA
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0 Pain Relevance 0
Groups 1, 2, and 3 (24 rabbits in each group, 12 males and 12 females) were each given 80 µg Pfs25/ISA 51 vaccine, 80 µg Pvs25/ISA 51 vaccine, or PBS/ISA 51 in a volume of 0.5 mL, respectively.
Gene_expression (vaccine) of ISA
4) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0.11 Pain Relevance 0
Despite the lack of issues identified in preclinical studies including a toxicology study conducted in rabbits, both Pfs25/ISA 51 and Pvs25/ISA 51 proved to be quite reactogenic in humans.
Gene_expression (/) of ISA
5) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0.46 Pain Relevance 0.05
Groups 1, 2, and 3 (24 rabbits in each group, 12 males and 12 females) were each given 80 µg Pfs25/ISA 51 vaccine, 80 µg Pvs25/ISA 51 vaccine, or PBS/ISA 51 in a volume of 0.5 mL, respectively.
Gene_expression (vaccine) of ISA
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0.11 Pain Relevance 0
Groups 1, 2, and 3 (24 rabbits in each group, 12 males and 12 females) were each given 80 µg Pfs25/ISA 51 vaccine, 80 µg Pvs25/ISA 51 vaccine, or PBS/ISA 51 in a volume of 0.5 mL, respectively.
Gene_expression (vaccine) of ISA
7) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0.10 Pain Relevance 0
Ten volunteers in each of the 5 µg Pvs25/ISA 51, 20 µg Pvs25/ISA 51, and 5 µg Pfs25/ISA 51 dose groups were enrolled and received their first vaccinations.
Gene_expression (/) of ISA
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0 Pain Relevance 0
The trigger to cease vaccination was development of erythema nodosum like symptoms in 2 of 10 volunteers who received 20 µg Pvs25/ISA 51.
Gene_expression (received) of ISA associated with vasculitis
9) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 1.17 Pain Relevance 0.05

General Comments

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