INT237038

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 13.68
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Becn1) cytoplasmic membrane-bounded vesicle (Becn1) cytoskeleton (Becn1)
cell cycle (Becn1) cell division (Becn1) protein complex (Becn1)
Anatomy Link Frequency
neuronal 2
brains 1
groove 1
band 1
Becn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 92.88 High High
Inflammation 20 90.64 High High
Pyramidal cell 12 62.40 Quite High
chemokine 5 59.04 Quite High
depression 6 28.72 Quite Low
Clonidine 32 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
halothane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 167 100.00 Very High Very High Very High
Infection 457 99.84 Very High Very High Very High
Alzheimer's Dementia 74 99.84 Very High Very High Very High
Sprains And Strains 37 99.84 Very High Very High Very High
Targeted Disruption 77 99.72 Very High Very High Very High
Apoptosis 770 99.68 Very High Very High Very High
Parkinson's Disease 154 99.08 Very High Very High Very High
Togavirus Infection 82 99.08 Very High Very High Very High
Urological Neuroanatomy 2 98.60 Very High Very High Very High
Disease 389 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include Ifi27, Ifih1, Irf7 and Oas1b which were upregulated at 72 hr and 96 hr post infection except Becn1 that was over-expressed only at 72 hr post infection, and Spn which was over-expressed at all time points.


Gene_expression (expressed) of Becn1 associated with urological neuroanatomy and infection
1) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.43 Pain Relevance 0.23
Levels of other components of the autophagy pathway such as Atg5, Atg10, Atg12 and Beclin-1 were not different in DLB compared to controls.
Gene_expression (Levels) of Beclin-1 associated with parkinson's disease
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.56 Pain Relevance 0
Beclin-1 was detected as a single band at 50 kDa that was more abundant in the membrane than the cytosolic fraction (Figure 1A, B).
Gene_expression (detected) of Beclin-1 in band
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.92 Pain Relevance 0.03
The elevated expression of Beclin-1 and LC3-II following lethal toxin exposure was further substantiated by the overtly increased GFP-LC3 puncta staining in H9C2 cells following lethal toxin challenge.
Gene_expression (expression) of Beclin-1
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.64 Pain Relevance 0.03
Assessment of ER stress and autophagy revealed a significant increase in Bip, Beclin-1 and LC3-II expression following lethal toxin exposure, suggesting possible involvements of ER stress and autophagy.
Gene_expression (expression) of Beclin-1 associated with stress
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.59 Pain Relevance 0.03
Conversely, increasing Beclin 1 expression results in diminished amyloid pathology in these AD transgenic mice [57].
Gene_expression (expression) of Beclin 1 associated with targeted disruption and alzheimer's dementia
6) Confidence 0.14 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.58 Pain Relevance 0
One probable contributor to autophagy deficiency in AD appears to be Beclin 1, whose expression is strongly reduced in the brains of AD patients to levels that would be predicted to impair autophagosome synthesis [56].
Gene_expression (expression) of Beclin 1 in brains associated with alzheimer's dementia
7) Confidence 0.12 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.47 Pain Relevance 0
Genetic manipulations that decrease Beclin 1 levels in AD transgenic mice reduce neuronal autophagy, disrupt lysosomes, promote intracellular and extracellular A?
Gene_expression (levels) of Beclin 1 in neuronal associated with targeted disruption and alzheimer's dementia
8) Confidence 0.12 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.58 Pain Relevance 0
Recently, delivery of the Beclin 1 gene was shown to induce autophagy and reduce amyloid and ?
Gene_expression (delivery) of Beclin 1 gene associated with alzheimer's dementia
9) Confidence 0.12 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.94 Pain Relevance 0
Our results revealed that lethal toxin produced subtle although significant upregulation in the expression of the ER stress maker BIP and the autophagy markers Beclin-1 and LC3-II without affecting the phospho-eIF2?
Gene_expression (expression) of Beclin-1 associated with stress
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.57 Pain Relevance 0
Neuronal overexpression of the autophagy protein Beclin1 confers resistance to Sindbis virus infections [7].
Gene_expression (overexpression) of Beclin1 in Neuronal associated with togavirus infection and infection
11) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.72 Pain Relevance 0
BH2 mutant defective for apoptosis inhibition yet retaining Beclin1-binding and autophagy inhibition intact maintained viral genome loads equivalent to WT virus (Figure 7D, 7E, 7F down and S5D), arguing that the ?
Gene_expression (retaining) of Beclin1-binding associated with apoptosis
12) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.46 Pain Relevance 0
These data collectively demonstrate that the BH2 domain of the hydrophobic groove of vBcl-2 is not essential for suppressing Beclin1-mediated autophagy and its elimination does not affect Beclin1 binding, whereas the elimination of ?
Gene_expression (suppressing) of Beclin1 in groove
13) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
In contrast, 3T3 cells infected with the Beclin1-binding-deficient vBcl-2 mutant viruses (?
Gene_expression (infected) of Beclin1-binding
14) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.08 Pain Relevance 0
To analyze the interactions between the Beclin1 and vBcl-2 mutants, yeast strain AH109, expressing the BH3-like domain of Beclin1 fused to the Gal4 activation domain in the pGADT7 plasmid, was used to transform pGBKT7 plasmids containing the mutants of vBcl-2, and the transformants then assayed for ?
Spec (analyze) Gene_expression (mutants) of Beclin1 associated with sprains and strains
15) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.30 Pain Relevance 0
To analyze the interactions between the Beclin1 and vBcl-2 mutants, yeast strain AH109, expressing the BH3-like domain of Beclin1 fused to the Gal4 activation domain in the pGADT7 plasmid, was used to transform pGBKT7 plasmids containing the mutants of vBcl-2, and the transformants then assayed for ?
Gene_expression (expressing) of Beclin1 associated with sprains and strains
16) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.31 Pain Relevance 0
Similar results were also observed with endogenous Beclin1 in 293T cells, in that removal of the ?
Gene_expression (observed) of Beclin1
17) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
(F) The superoxide generating agent menadione increases LC3-II and phosphorylation of JNK and Bcl-2, but has no effect on mTOR substrates or Beclin-1 expression.
Gene_expression (expression) of Beclin-1
18) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.06 Pain Relevance 0
Previous work has shown that oxidative stress in the form of hydrogen peroxide can increase the expression of Beclin-1 and thus induce autophagy (27).
Gene_expression (expression) of Beclin-1 associated with stress
19) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.17 Pain Relevance 0
We did not find that thiol antioxidants or vitamin E had any significant effect on levels of Beclin-1 (Fig. 6D and E).
Gene_expression (levels) of Beclin-1
20) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.16 Pain Relevance 0

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