INT237047

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.04
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl11) extracellular region (Cxcl11)
Anatomy Link Frequency
lymph node 2
T cells 2
Cxcl11 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 119 100.00 Very High Very High Very High
Inflammation 65 96.36 Very High Very High Very High
cytokine 44 95.44 Very High Very High Very High
Central nervous system 11 78.36 Quite High
Crohn's disease 51 64.40 Quite High
interstitial cystitis 41 43.08 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 140 99.76 Very High Very High Very High
Cystitis 70 99.44 Very High Very High Very High
Disease 112 99.08 Very High Very High Very High
Infection 119 98.08 Very High Very High Very High
Togavirus Infection 75 97.36 Very High Very High Very High
Sprains And Strains 40 96.40 Very High Very High Very High
INFLAMMATION 70 96.36 Very High Very High Very High
Viral Meningitis 4 89.12 High High
Disease Progression 11 87.76 High High
Apoptosis 17 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Cxcl11 associated with chemokine
1) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.91 Pain Relevance 0.63
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Positive_regulation (increases) of Gene_expression (expression) of CXCL11 in lymph node associated with cystitis
2) Confidence 0.39 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.71 Pain Relevance 0.10
PP and MLN DCs expressed elevated levels of CXCL9 and CXCL11, but not CXCL10, during Mycobacteria-enhanced colitis as indicated by their relative mean fluorescent intensities (Figure 5A).
Positive_regulation (elevated) of Gene_expression (expressed) of CXCL11 associated with colitis
3) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.56 Pain Relevance 0.08
The expression of CXCR3 and its ligands (CXCL10 >> CXCL11 or CXCL9) by mucosal T cells significantly increased in mice challenged with live Mycobacteria than compared with similar mice challenged with heat-killed Mycobacteria or controls.
Positive_regulation (increased) of Gene_expression (expression) of CXCL11 in T cells
4) Confidence 0.32 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.15 Pain Relevance 0.14
In the present study, we demonstrate that the murine interferon-inducible ELR- CXC chemokines CXCL9, CXCL10, and/or CXCL11 exert direct antimicrobial effects against toxigenic, unencapsulated B. anthracis Sterne strain (pXO1+ pXO2?)
Positive_regulation (murine) of Gene_expression (/) of CXCL11 associated with chemokine and sprains and strains
5) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.71 Pain Relevance 0.21

General Comments

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