INT237051

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 28
Disease Relevance 25.74
Pain Relevance 5.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl11) extracellular region (Cxcl11)
Anatomy Link Frequency
spore 3
T cell 2
lymph node 1
leukocytes 1
lymphocyte 1
Cxcl11 (Mus musculus)
Pain Link Frequency Relevance Heat
interstitial cystitis 410 99.68 Very High Very High Very High
chemokine 672 99.62 Very High Very High Very High
Inflammatory stimuli 5 99.36 Very High Very High Very High
cytokine 347 98.92 Very High Very High Very High
Inflammation 481 98.82 Very High Very High Very High
Crohn's disease 239 90.52 High High
rheumatoid arthritis 88 85.20 High High
Central nervous system 13 78.36 Quite High
Lasting pain 10 75.08 Quite High
Inflammatory response 53 69.52 Quite High
Disease Link Frequency Relevance Heat
Colitis 641 99.76 Very High Very High Very High
Interstitial Cystitis 410 99.68 Very High Very High Very High
INFLAMMATION 529 99.36 Very High Very High Very High
Inflammatory Bowel Disease 203 99.18 Very High Very High Very High
Injury 205 99.12 Very High Very High Very High
Cystitis 700 99.10 Very High Very High Very High
Disease 634 99.08 Very High Very High Very High
Pressure And Volume Under Development 18 97.64 Very High Very High Very High
Togavirus Infection 75 97.36 Very High Very High Very High
Sprains And Strains 198 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum CXCL9, CXCL10, and CXCL11 levels of CYP-treated mice given control Ab were compared to similar mice that received anti-CXCL10 Ab.
Gene_expression (levels) of CXCL11
1) Confidence 0.64 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.31 Pain Relevance 0.42
By contrast, IL-6, IP-10 (CXCL10) and I-TAC (CXCL11) expression peaked at day 1 post injury and then gradually declined over the subsequent 6 days.
Gene_expression (expression) of I-TAC associated with injury
2) Confidence 0.58 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2889944 Disease Relevance 1.84 Pain Relevance 0.34
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Gene_expression (genes) of Cxcl11 associated with chemokine
3) Confidence 0.58 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.84 Pain Relevance 0.60
In the present study, we show that CXCL9 and CXCL11 are predominantly produced by DCs in the MLN as well as in PP and to a lesser degree in the intestinal LP.
Gene_expression (produced) of CXCL11
4) Confidence 0.57 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.48 Pain Relevance 0.08
The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge.
Gene_expression (expressing) of CXCL11 associated with colitis
5) Confidence 0.57 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.61 Pain Relevance 0.06
Our results also suggest plasmacytoid > > myeloid DCs express CXCL9 and CXCL11, but less CXCL10 as well as IFN-?
Gene_expression (express) of CXCL11
6) Confidence 0.57 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.83 Pain Relevance 0.06
PP and MLN DCs expressed elevated levels of CXCL9 and CXCL11, but not CXCL10, during Mycobacteria-enhanced colitis as indicated by their relative mean fluorescent intensities (Figure 5A).
Gene_expression (expressed) of CXCL11 associated with colitis
7) Confidence 0.57 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.56 Pain Relevance 0.08
The selective expression of CXCL9 and CXCL11 by plasmacytoid and myeloid DCs suggests a differential role for these cells in the attraction of specific lymphocyte subsets [10] as well as in the preferential recruitment and activation of Th1 cells [11,32].
Gene_expression (expression) of CXCL11 in lymphocyte
8) Confidence 0.57 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.39 Pain Relevance 0.08
The expression of CXCL9, CXCL10, and CXCL11 can be induced by IFN-?
Gene_expression (expression) of CXCL11
9) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.55 Pain Relevance 0.18
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Gene_expression (expression) of CXCL11 in lymph node associated with cystitis
10) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.70 Pain Relevance 0.10
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Gene_expression (expression) of CXCL11 in T cell
11) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.24 Pain Relevance 0.38
Anti-CXCL10 Ab treatment significantly decreased the expression of CXCL9 and CXCR3 mRNAs by iliac lymph node leukocytes and reduced the production of CXCL9, CXCL10, CXCL11, and CXCR3 mRNAs by urinary bladder leukocytes.
Gene_expression (production) of CXCL11 in leukocytes
12) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.53 Pain Relevance 0.15
Serum CXCL9, CXCL10, and CXCL11 expression during IC
Gene_expression (expression) of CXCL11 associated with interstitial cystitis
13) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.35 Pain Relevance 0.28
We show that serum levels of CXCL9, CXCL10, and CXCL11 were increased in IC patients.
Gene_expression (levels) of CXCL11 associated with interstitial cystitis
14) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.22 Pain Relevance 0.37
Serum CXCL9, CXCL10, and CXCL11 levels in mice after CYP induction
Gene_expression (levels) of CXCL11
15) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.78 Pain Relevance 0.37
CXCL9, CXCL10, CXCL11, and CXCR3 mRNA expression
Gene_expression (expression) of CXCL11
16) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.78 Pain Relevance 0.10
The expression of CXCR3 and its ligands (CXCL10 >> CXCL11 or CXCL9) by mucosal T cells significantly increased in mice challenged with live Mycobacteria than compared with similar mice challenged with heat-killed Mycobacteria or controls.
Gene_expression (expression) of CXCL11 in T cells
17) Confidence 0.50 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.14 Pain Relevance 0.14
As with these innate immunity cells, neutrophils are compartmentalized in the MLN and tightly regulated to differentially express CXCL9 and CXCL11, CXCR3 and Th1-associated cytokines during Mycobacteria-mediated colitis.
Gene_expression (express) of CXCL11 in neutrophils associated with colitis and cytokine
18) Confidence 0.49 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.81 Pain Relevance 0.05
By contrast, IL-6, IP-10 (CXCL10) and I-TAC (CXCL11) expression peaked at day 1 post injury and then gradually declined over the subsequent 6 days.
Gene_expression (expression) of CXCL11 associated with injury
19) Confidence 0.49 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2889944 Disease Relevance 1.84 Pain Relevance 0.34
These results suggest that IBD patients have higher CXCL9, CXCL10, and CXCL11 levels and Mycobacteria-specific IgG1 and IgG2 Ab responses.
Gene_expression (levels) of CXCL11 associated with inflammatory bowel disease
20) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.99 Pain Relevance 0.11

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