INT237054

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 10.26
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
retinas 2
lymphocyte 2
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 108 100.00 Very High Very High Very High
Inflammatory response 28 99.80 Very High Very High Very High
cytokine 124 99.22 Very High Very High Very High
ischemia 19 98.80 Very High Very High Very High
Inflammation 251 97.80 Very High Very High Very High
interstitial cystitis 164 97.80 Very High Very High Very High
fibrosis 221 96.64 Very High Very High Very High
Inflammatory mediators 6 69.76 Quite High
agonist 1 67.84 Quite High
Central nervous system 15 60.72 Quite High
Disease Link Frequency Relevance Heat
Infection 109 100.00 Very High Very High Very High
INFLAMMATION 268 99.62 Very High Very High Very High
Brain Hemorrhage 5 98.80 Very High Very High Very High
Immunization 22 98.50 Very High Very High Very High
Interstitial Cystitis 164 97.80 Very High Very High Very High
Togavirus Infection 75 97.24 Very High Very High Very High
Pulmonary Fibrosis 156 96.64 Very High Very High Very High
Cystitis 280 96.08 Very High Very High Very High
Atherosclerosis 204 94.72 High High
Atherosclerotic Plaque 38 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Negative_regulation (reduced) of Gene_expression (expression) of Cxcl10 in retinas
1) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.98 Pain Relevance 0.35
We found that high-tidal-volume ventilation increased production of MIP-2 but reduced production of IP-10 (Figure 1c,d).
Negative_regulation (reduced) of Gene_expression (production) of IP-10
2) Confidence 0.43 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.66 Pain Relevance 0.29
CSF-1 induced expression of the proatherogenic chemokines CXCL10/IP-10, CCL2 and CCL7 but repressed expression of the antiatherogenic chemokine receptor CXCR4 [53].
Negative_regulation (chemokines) of Gene_expression (expression) of CXCL10 associated with chemokine
3) Confidence 0.41 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.78 Pain Relevance 0.27
CSF-1 induced expression of the proatherogenic chemokines CXCL10/IP-10, CCL2 and CCL7 but repressed expression of the antiatherogenic chemokine receptor CXCR4 [53].
Negative_regulation (repressed) of Gene_expression (expression) of CXCL10 associated with chemokine
4) Confidence 0.41 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.89 Pain Relevance 0.30
The ability of CXCL10 blockade to modulate local chemokines as well as Th1 cytokine mRNA expression and to facilitate the decline of serum levels of CXCL9 and CXCL10 is an indication of reduced local as well as systemic inflammation.
Negative_regulation (decline) of Gene_expression (levels) of CXCL10 associated with chemokine, inflammation and cytokine
5) Confidence 0.41 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.75 Pain Relevance 0.36
The described study shows that anti-CXCL10 Ab therapy reduces TNF-?
Negative_regulation (reduces) of Gene_expression (therapy) of CXCL10
6) Confidence 0.40 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.67 Pain Relevance 0.57
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Negative_regulation (reduced) of Gene_expression (blockade) of CXCL10
7) Confidence 0.40 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.23
Interestingly, the mouse cxcl10 promoter has seven ?
Negative_regulation (seven) of Gene_expression (has) of cxcl10 promoter
8) Confidence 0.40 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.01 Pain Relevance 0.48
Increased production of MIP-2 but reduced production of IP-10 was found in mice ventilated at 30 ml/kg VT compared with control, nonventilated mice and compared with mice ventilated at 6 ml/kg VT.
Negative_regulation (reduced) of Gene_expression (production) of IP-10
9) Confidence 0.37 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.37 Pain Relevance 0.14
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Negative_regulation (infection) of Gene_expression (expression) of Cxcl10 associated with inflammatory response and infection
10) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.97 Pain Relevance 0.05
Our data show that vault immunization results in the production of factors associated with increased lymphocyte recruitment such as CXCL10 production.
Negative_regulation (recruitment) of Gene_expression (production) of CXCL10 in lymphocyte associated with immunization
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.75 Pain Relevance 0.11
This resulted in antifibrogenic signals, including growth inhibition but also the increased expression of the IFN-inducible chemokine CXCL10.
Negative_regulation (inhibition) of Gene_expression (expression) of CXCL10 associated with chemokine
12) Confidence 0.24 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.46 Pain Relevance 0.24

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