INT237075

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.18
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spn)
Anatomy Link Frequency
mature B cells 1
nerve 1
T cells 1
Spn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 97.92 Very High Very High Very High
Inflammation 92 95.68 Very High Very High Very High
Peripheral nervous system 7 93.36 High High
chemokine 15 64.08 Quite High
cytokine 45 48.40 Quite Low
Kinase C 4 29.28 Quite Low
Action potential 5 15.64 Low Low
Central nervous system 23 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 258 100.00 Very High Very High Very High
Urological Neuroanatomy 17 100.00 Very High Very High Very High
Hematological Disease 4 98.22 Very High Very High Very High
INFLAMMATION 109 97.92 Very High Very High Very High
Hypergammaglobulinemia 4 97.28 Very High Very High Very High
Vasculitis 84 95.64 Very High Very High Very High
Aging 103 92.20 High High
Togavirus Infection 150 87.68 High High
Severe Acute Respiratory Syndrome 38 72.40 Quite High
Parasitemia 13 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include Ifi27, Ifih1, Irf7 and Oas1b which were upregulated at 72 hr and 96 hr post infection except Becn1 that was over-expressed only at 72 hr post infection, and Spn which was over-expressed at all time points.


Gene_expression (expressed) of Spn associated with urological neuroanatomy and infection
1) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.41 Pain Relevance 0.23
These include Ifi27, Ifih1, Irf7 and Oas1b which were upregulated at 72 hr and 96 hr post infection except Becn1 that was over-expressed only at 72 hr post infection, and Spn which was over-expressed at all time points.


Gene_expression (expressed) of Spn associated with urological neuroanatomy and infection
2) Confidence 0.33 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.47 Pain Relevance 0.24
S4 A and B), compared to PBS treatment, as determined by CD43 (clone 1B11) expression.
Spec (determined) Gene_expression (expression) of CD43
3) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.23 Pain Relevance 0
They showed that CD4+ T cells from old mice express unusually high levels of glycosylated forms of the T cell glycoprotein CD43, particularly on a subset of functionally anergic cells expressing P-glycoprotein.
Gene_expression (express) of CD43 in T cells
4) Confidence 0.15 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.29 Pain Relevance 0
Altogether, these results suggest that the process of B cell hematopoiesis is disturbed in the bone marrow and may be instrumental in the subsequently diminishing production of mature B cells (CD19+IgM+CD43?)
Gene_expression (production) of CD43 in mature B cells associated with hematological disease
5) Confidence 0.14 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.78 Pain Relevance 0
One study of NSVN patients did compare the sensitivity of SPN/PBM versus sural nerve biopsy in the diagnosis of definite vasculitis and found increased sensitivity of 58% versus 47%, respectively, but this was not statistically significant.6 A recent study comparing complications following SPN/PBM versus sural nerve biopsy has shown that although SPN biopsy can lead to a greater area of sensory loss compared with sural nerve biopsy, there is very little difference in other complications.24 Differences in the published diagnostic yield of combined nerve and muscle biopsy may also relate to the case mix (eg, the proportion of SVN versus NSVN cases) and the stringency of the criteria used to define vasculitis in peripheral nerve and muscle.
Gene_expression (biopsy) of SPN in nerve associated with peripheral nervous system, urological neuroanatomy and vasculitis
6) Confidence 0.05 Published 2008 Journal Journal of Neurology, Neurosurgery, and Psychiatry Section Body Doc Link PMC2582330 Disease Relevance 1.01 Pain Relevance 0.09

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