INT237154

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.99
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LGALS4, KIT) cytosol (LGALS4) signal transduction (KIT)
extracellular space (KIT) cell adhesion (LGALS4) nucleus (KIT)
LGALS4 (Homo sapiens)
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 84 99.72 Very High Very High Very High
Inflammation 111 98.44 Very High Very High Very High
Potency 3 65.44 Quite High
Adalimumab 6 58.24 Quite High
Crohn's disease 12 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 60 99.44 Very High Very High Very High
Apoptosis 162 99.40 Very High Very High Very High
Inflammatory Bowel Disease 54 99.14 Very High Very High Very High
INFLAMMATION 81 98.44 Very High Very High Very High
Necrosis 9 83.76 Quite High
Targeted Disruption 3 83.08 Quite High
Colitis 51 75.72 Quite High
Mucositis 30 5.00 Very Low Very Low Very Low
Disease 27 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of cytokine secretion in stimulated PBT and LPT by Gal-4
Gal-4 Positive_regulation (stimulated) of PBT associated with cytokine
1) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19
The idea that Gal-4 might restore naturally occurring anti-inflammatory systems which are defective in IBD was substantiated by our observation that Gal-4 potently induces PBT, but also LPT apoptosis.
Gal-4 Positive_regulation (induces) of PBT associated with inflammatory bowel disease, inflammation and apoptosis
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.15 Pain Relevance 0.21
Using the externalization of phosphatidylserine as a marker of cell apoptosis and positive DNA staining as an indication of membrane leakage, we tested the ability of Gal-4 to induce PBT and LPT cell death.
Gal-4 Positive_regulation (induce) of PBT associated with apoptosis and death
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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