INT237161

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.71
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Ccnb1) cytoplasm (Ccnb1) mitosis (Ccnb1)
nucleus (Ccnb1) cytoskeleton (Ccnb1) cell cycle (Ccnb1)
Anatomy Link Frequency
M cell 1
cervix 1
Ccnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 98.22 Very High Very High Very High
Pyramidal cell 26 96.32 Very High Very High Very High
cytokine 35 60.76 Quite High
Inflammation 54 60.36 Quite High
Thoracotomy 6 50.24 Quite High
positron emission tomography 16 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 35 99.22 Very High Very High Very High
Apoptosis 116 99.00 Very High Very High Very High
INFLAMMATION 49 98.02 Very High Very High Very High
Disease 47 93.36 High High
Retinoblastoma 2 93.12 High High
Skin Cancer 7 89.40 High High
Leukemia 1 88.84 High High
Cancer 107 88.72 High High
Lymphatic System Cancer 1 88.44 High High
Non-small-cell Lung Cancer 26 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, at 7 days, the top networks are focused on immunomodulation and inflammatory responses (up-regulation of NPPA/ANP and Brca1 - Figure 5A), and continued cell proliferation (up-regulation of Birc5, Foxm1, Cdc2, Ccnb1 and Ccna2 - Figure 5B).


Regulation (regulation) of Ccnb1 associated with inflammatory response
1) Confidence 0.17 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.42 Pain Relevance 0.23
In agreement with these observations, a high differential expression of cyclin B1 was consistently found in skin from K14E6 as compared to nontrangenic mice, but we did not see significant modulation of cyclin B1 or other components of the cell cycle control in cervix from K14E6 mice.
Regulation (modulation) of cyclin B1 in cervix
2) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.50 Pain Relevance 0
The analysis of cyclin A, regulating the S-phase, and cyclin B1, propelling the cells from late G2 to mitosis, was measured in conjunction with propidium iodide (PI) staining to exactly localize its increase within the cell cycle and to exclude dead cells.
Regulation (regulating) of cyclin B1
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Upregulation of cyclinB1 also points to the G2/M checkpoint, which depends on cdk2/cyclinB1 activity.
Regulation (depends) of cyclinB1
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.52 Pain Relevance 0.09
Furthermore, lapatinib induced G1 cell cycle arrest (P < 0.0001) and apoptotic cell death (P < 0.0006) and reduced cyclin A and B1 levels, which are regulators of S and G2/M cell cycle stages, respectively.
Regulation (regulators) of B1 in M cell associated with apoptosis and death
5) Confidence 0.00 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2883966 Disease Relevance 1.00 Pain Relevance 0
A possible reason for this cell cycle effect is the decrease in the protein levels of cyclins A and B1, which are regulators of S and G2/M phases, respectively.
Regulation (regulators) of B1
6) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.26 Pain Relevance 0

General Comments

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