INT237179

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.46
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LGALS4) cell adhesion (LGALS4) plasma membrane (LGALS4)
Anatomy Link Frequency
alimentary tract 2
T cell 2
LGALS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 222 96.92 Very High Very High Very High
cytokine 168 88.32 High High
abdominal pain 6 85.84 High High
Inflammatory response 6 64.20 Quite High
Bile 1 32.48 Quite Low
cINOD 6 25.04 Quite Low
Crohn's disease 24 10.56 Low Low
Adalimumab 12 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 162 96.92 Very High Very High Very High
Cancer 12 94.88 High High
Amebiasis 1 93.76 High High
Abdominal Pain 6 85.84 High High
Colitis 102 80.36 Quite High
Infection 5 76.80 Quite High
Of Sheep Progressive Interstitial Pneumonia 3 72.48 Quite High
Visna 3 72.24 Quite High
Inflammatory Bowel Disease 108 70.00 Quite High
Mucositis 60 69.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the same experimental design as above, we transfected PBT with specific Gal-4 antisense to investigate the role of endogenous Gal-4.
Positive_regulation (transfected) of Spec (investigate) Gene_expression (transfected) of Gal-4
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.20
Immunohistochemistry for Gal-4 expression
Positive_regulation (for) of Gene_expression (expression) of Gal-4
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.47 Pain Relevance 0.21
Immunohistochemistry for Gal-4 expression
Positive_regulation (Immunohistochemistry) of Gene_expression (expression) of Gal-4
3) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.53 Pain Relevance 0.21
By performing sequential immunohistochemical analysis, we showed strong Gal-4 expression in epithelial cells along the alimentary tract and thus confirmed the previously described RNA expression profile [7].
Positive_regulation (strong) of Gene_expression (expression) of Gal-4 in alimentary tract
4) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.45 Pain Relevance 0.15
Gal-4 inhibits T cell activation and proliferation
Positive_regulation (activation) of Gene_expression (proliferation) of Gal-4 in T cell
5) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Using the same experimental design as above, we transfected PBT with specific Gal-4 antisense to investigate the role of endogenous Gal-4.
Positive_regulation (transfected) of Gene_expression (antisense) of Gal-4
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.20
This association was particularly interesting to author GKW as it suggests that this protozoan might be responsive to as-yet-uncharacterized GATA-like or Gal4-like transcription factors as a trigger for the expression of the multi-drug resistance trait.
Positive_regulation (trigger) of Gene_expression (expression) of Gal4-like
7) Confidence 0.31 Published 2010 Journal J Biomed Discov Collab Section Body Doc Link PMC2990276 Disease Relevance 1.01 Pain Relevance 0

General Comments

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