INT237181

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.18
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LGALS4) cell adhesion (LGALS4) plasma membrane (LGALS4)
Anatomy Link Frequency
T cell 6
LGALS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 14 97.72 Very High Very High Very High
Potency 7 91.20 High High
cytokine 196 88.88 High High
Inflammation 259 84.16 Quite High
Crohn's disease 28 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
abdominal pain 7 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 378 99.16 Very High Very High Very High
Death 140 96.68 Very High Very High Very High
Necrosis 21 90.96 High High
Inflammatory Bowel Disease 126 85.56 High High
INFLAMMATION 189 84.16 Quite High
Targeted Disruption 7 70.36 Quite High
Colitis 119 63.00 Quite High
Mucositis 70 5.00 Very Low Very Low Very Low
Disease 63 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in contrast to the lack of Gal-4 antisense to interfere with the T cell cycle, blockade of Gal-4 expression increased TNF-?
Negative_regulation (blockade) of Gene_expression (expression) of Gal-4 in T cell
1) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19
Gal-4 expression was inhibited by 49±7%.
Negative_regulation (inhibited) of Gene_expression (expression) of Gal-4
2) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19
As verified by TaqMan real time PCR, Gal-4 expression was inhibited by the specific antisense oligonucleotides by 49±7%.
Negative_regulation (inhibited) of Gene_expression (expression) of Gal-4
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Indeed, blockade of Gal-4 expression by specific antisense oligonucleotides modestly reduced adalimumab-induced T cell death from 63% of cells to 53% (Fig 5C).
Negative_regulation (blockade) of Gene_expression (expression) of Gal-4 in T cell associated with adalimumab and death
4) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.93 Pain Relevance 0.08
Therefore, we down-regulated Gal-4 expression with specific antisense oligonucleotides.
Negative_regulation (down) of Gene_expression (expression) of Gal-4
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Therefore, we down-regulated Gal-4 expression with specific antisense oligonucleotides.
Negative_regulation (regulated) of Gene_expression (expression) of Gal-4
6) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Uncovering the involvement of Gal-4 in the apoptotic program of T cells and assigning a new biological role to endogenous Gal-4, in deed, inhibition of Gal-4 expression by specific antisense oligonucleotides decreased TNF-?
Negative_regulation (inhibition) of Gene_expression (expression) of Gal-4 in T cells associated with apoptosis
7) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.25 Pain Relevance 0.14

General Comments

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