INT237186

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.00
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LGALS4) cell adhesion (LGALS4) plasma membrane (LGALS4)
Anatomy Link Frequency
T cells 1
LGALS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 8 92.96 High High
addiction 4 89.92 High High
Inflammation 148 71.04 Quite High
cytokine 112 55.88 Quite High
abdominal pain 4 24.28 Low Low
Crohn's disease 16 21.32 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 216 80.72 Quite High
Colitis 68 74.72 Quite High
INFLAMMATION 108 71.04 Quite High
Inflammatory Bowel Disease 72 62.36 Quite High
Abdominal Pain 4 24.28 Low Low
Disease 36 21.32 Low Low
Necrosis 12 19.20 Low Low
Cancer 8 18.84 Low Low
Mucositis 40 11.56 Low Low
Death 80 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total RNA was isolated using RNA Bee RNA isolation solvent (Tel-Test Inc.). 2.5 µg of total RNA were reverse transcribed and Gal-4-specific mRNA was amplified using the following primers: sense 5?
Transcription (transcribed) of Gal-4
1) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.08 Pain Relevance 0.04
Accordingly, Gal-4 mRNA expression in T cells was weak, but detectable (Fig. 1B) using GAPDH as a house-keeping gene.
Transcription (expression) of Gal-4 in T cells
2) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.51 Pain Relevance 0.15
When the Gal-4 expression was quantified on the protein level, Gal-4 was detected intra- and extracellularly in PBMC, regardless of their activation status (Fig. 1C).
Transcription (detected) of Gal-4
3) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.41 Pain Relevance 0.09
Following isolation of total RNA with RNA Bee, the efficacy of the specific siRNA to downregulate Gal-4 mRNA expression was determined by a TaqMan real-time PCR on a MxPro 3000 (Stratagene, CA) and quantified with Sybr®Green (Applied Biosystems).
Transcription (expression) of Gal-4
4) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.05

General Comments

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