INT237187

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.01
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LGALS4) cell adhesion (LGALS4) plasma membrane (LGALS4)
Anatomy Link Frequency
T cell 3
LGALS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 111 89.68 High High
cytokine 84 88.64 High High
Adalimumab 6 84.60 Quite High
Crohn's disease 12 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 162 99.36 Very High Very High Very High
Death 60 97.04 Very High Very High Very High
INFLAMMATION 81 89.68 High High
Colitis 51 83.60 Quite High
Mucositis 30 81.04 Quite High
Necrosis 9 71.76 Quite High
Inflammatory Bowel Disease 54 5.00 Very Low Very Low Very Low
Disease 27 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in contrast to the lack of Gal-4 antisense to interfere with the T cell cycle, blockade of Gal-4 expression increased TNF-?
Negative_regulation (lack) of Gal-4 in T cell
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19
Providing further evidence for its important role in regulating T cell function, galectin-4 blockade by antisense oligonucleotides reduced TNF-alpha inhibitor induced T cell death.
Negative_regulation (blockade) of galectin-4 in T cell associated with death
2) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2440804 Disease Relevance 0.86 Pain Relevance 0.27
Furthermore, treatment with 10 nM and 1 ┬ÁM cycloheximide did not inhibit Gal-4 induced T cell apoptosis, indicating that abolishment of de novo protein synthesis is not required for its proapoptotic activity (not shown).
Negative_regulation (inhibit) of Gal-4 in T cell associated with apoptosis
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.14 Pain Relevance 0.07

General Comments

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