INT237195

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LGALS4) cell adhesion (LGALS4) plasma membrane (LGALS4)
Anatomy Link Frequency
T cells 1
LGALS4 (Homo sapiens)
LPT (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 112 99.72 Very High Very High Very High
Inflammation 148 98.44 Very High Very High Very High
addiction 4 78.88 Quite High
Potency 4 66.56 Quite High
Adalimumab 8 58.88 Quite High
abdominal pain 4 46.64 Quite Low
Crohn's disease 16 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 216 99.96 Very High Very High Very High
Death 80 99.76 Very High Very High Very High
Inflammatory Bowel Disease 72 99.14 Very High Very High Very High
INFLAMMATION 108 98.44 Very High Very High Very High
Necrosis 12 84.40 Quite High
Targeted Disruption 4 83.08 Quite High
Colitis 68 75.72 Quite High
Abdominal Pain 4 46.64 Quite Low
Cancer 8 32.24 Quite Low
Mucositis 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of cytokine secretion in stimulated PBT and LPT by Gal-4
Gal-4 Positive_regulation (stimulated) of LPT associated with cytokine
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19
The idea that Gal-4 might restore naturally occurring anti-inflammatory systems which are defective in IBD was substantiated by our observation that Gal-4 potently induces PBT, but also LPT apoptosis.
Gal-4 Positive_regulation (induces) of LPT associated with inflammatory bowel disease, inflammation and apoptosis
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.15 Pain Relevance 0.21
Using the externalization of phosphatidylserine as a marker of cell apoptosis and positive DNA staining as an indication of membrane leakage, we tested the ability of Gal-4 to induce PBT and LPT cell death.
Gal-4 Positive_regulation (induce) of LPT associated with apoptosis and death
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.85 Pain Relevance 0.07
Determination of Gal-4 binding to T cells was performed by incubating resting and for 48 h CD3/CD28-stimulated PBT and CD2-stimulated LPT with 5 µg/ml Gal-4, a dose not able to induce T cell apoptosis.
Gal-4 Positive_regulation (stimulated) of LPT in T cells associated with apoptosis
4) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.15 Pain Relevance 0.06

General Comments

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