INT237204

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.61
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LGALS4, Cd3e) cytosol (LGALS4) cell adhesion (LGALS4)
signal transducer activity (Cd3e)
Anatomy Link Frequency
T cells 5
LGALS4 (Homo sapiens)
Cd3e (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 168 94.88 High High
cINOD 6 81.76 Quite High
Inflammation 222 81.28 Quite High
Crohn's disease 24 67.28 Quite High
Adalimumab 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 120 95.40 Very High Very High Very High
Colitis 102 91.96 High High
Apoptosis 324 91.68 High High
INFLAMMATION 162 81.52 Quite High
Inflammatory Bowel Disease 108 78.08 Quite High
Mucositis 60 76.68 Quite High
Disease 54 67.28 Quite High
Urological Neuroanatomy 24 54.48 Quite High
Targeted Disruption 6 31.04 Quite Low
Necrosis 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We could demonstrate that Gal-4 potently binds to activated T cells at the CD3 region which is translated in a potent inhibition of cell cycle progression and induction of antigen-induced cell death.
Gal-4 Binding (binds) of CD3 in T cells associated with death
1) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.33 Pain Relevance 0.38
The carbohydrate-dependent binding of galectin-4 at the CD3 epitope is fully functional and inhibited T cell activation, cycling and expansion.
galectin-4 Binding (binding) of CD3 in T cell
2) Confidence 0.11 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2440804 Disease Relevance 0.54 Pain Relevance 0.13
Here we provide novel evidence that galectin-4 is selectively expressed and secreted by intestinal epithelial cells and binds potently to activated peripheral and mucosal lamina propria T-cells at the CD3 epitope.
galectin-4 Binding (binds) of CD3 in T-cells
3) Confidence 0.11 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2440804 Disease Relevance 0.41 Pain Relevance 0.10
Gal-4 associates with CD3 but not with CD7 or ?
Gal-4 Binding (associates) of CD3
4) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
The strong down-regulation of CD25 expression of CD3-activated T cells by Gal-4 proves the biological consequence of the Gal-4 binding to the CD3 complex.
Gal-4 Binding (binding) of CD3 in T cells
5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.06 Pain Relevance 0.06
Proving the concept that the binding of extracellular Gal-4 is linked to the capacity of Gal-4 to inhibit cell cycling, blockade of endogenous Gal-4, which is not linked to the CD3 complex, failed to modulate T cell cycling.
Gal-4 Binding (linked) of CD3 in T cell
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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