INT237226

Context Info Confidence 0.59 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.78 Pain Relevance 0

cytoplasm (Plk1) mitosis (Plk1) chromosome (Plk1) nucleus (Plk1) cytoskeleton (Plk1) cell cycle (Plk1)

Anatomy Link Frequency bladder 1 Plk1 (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 4 5.00 tolerance 3 5.00 anesthesia 3 5.00 cytokine 2 5.00 analgesia 1 5.00 Deep tissue 1 5.00 Buprenorphine 1 5.00 interstitial cystitis 1 5.00 cva 1 5.00 intrathecal 1 5.00

Disease Link Frequency Relevance Heat Bladder Cancer 30 99.08 Cancer 36 80.12 Stress 1 71.12 Injury 7 63.92 Targeted Disruption 17 62.00 Hyperglycemia 2 51.60 Recurrence 22 5.00 Fever 10 5.00 Disease 7 5.00 Diabetes Mellitus 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).

Gene_expression (targets) of Plk1

1) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.12 Pain Relevance 0

Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.

Gene_expression (levels) of Plk1

2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0

Instillation of siRNA/cationic liposomes targeting polo-like kinase-1 or PLK-1, a biomarker of poor prognosis in a murine orthotopic bladder cancer model, resulted in significant inhibition of PLK-1 expression and lowering the PLK-1 protein level in bladder tissues, in a time- and dose-dependent manner (150).Another emerging experimental approach, still in preclinical evaluation, is using chemosensitizer to enhance the activity of agents with demonstrated clinical benefits.

Gene_expression (expression) of PLK-1 in bladder associated with bladder cancer

3) Confidence 0.11 Published 2008 Journal Pharm Res Section Body Doc Link PMC2440939 Disease Relevance 0.54 Pain Relevance 0

General Comments

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