INT237226

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Plk1) mitosis (Plk1) chromosome (Plk1)
nucleus (Plk1) cytoskeleton (Plk1) cell cycle (Plk1)
Anatomy Link Frequency
bladder 1
Plk1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Deep tissue 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
interstitial cystitis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 30 99.08 Very High Very High Very High
Cancer 36 80.12 Quite High
Stress 1 71.12 Quite High
Injury 7 63.92 Quite High
Targeted Disruption 17 62.00 Quite High
Hyperglycemia 2 51.60 Quite High
Recurrence 22 5.00 Very Low Very Low Very Low
Fever 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
Gene_expression (targets) of Plk1
1) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.12 Pain Relevance 0
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
Gene_expression (levels) of Plk1
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0
Instillation of siRNA/cationic liposomes targeting polo-like kinase-1 or PLK-1, a biomarker of poor prognosis in a murine orthotopic bladder cancer model, resulted in significant inhibition of PLK-1 expression and lowering the PLK-1 protein level in bladder tissues, in a time- and dose-dependent manner (150).Another emerging experimental approach, still in preclinical evaluation, is using chemosensitizer to enhance the activity of agents with demonstrated clinical benefits.
Gene_expression (expression) of PLK-1 in bladder associated with bladder cancer
3) Confidence 0.11 Published 2008 Journal Pharm Res Section Body Doc Link PMC2440939 Disease Relevance 0.54 Pain Relevance 0

General Comments

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