INT237227

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Plk1) mitosis (Plk1) chromosome (Plk1)
nucleus (Plk1) cytoskeleton (Plk1) cell cycle (Plk1)
Anatomy Link Frequency
bladder 2
Plk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Deep tissue 1 5.00 Very Low Very Low Very Low
interstitial cystitis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 30 99.36 Very High Very High Very High
Cancer 34 80.68 Quite High
Recurrence 22 5.00 Very Low Very Low Very Low
Fever 10 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Pox Virus Infection 5 5.00 Very Low Very Low Very Low
Carcinoma In Situ 3 5.00 Very Low Very Low Very Low
Disease Progression 3 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instillation of siRNA/cationic liposomes targeting polo-like kinase-1 or PLK-1, a biomarker of poor prognosis in a murine orthotopic bladder cancer model, resulted in significant inhibition of PLK-1 expression and lowering the PLK-1 protein level in bladder tissues, in a time- and dose-dependent manner (150).Another emerging experimental approach, still in preclinical evaluation, is using chemosensitizer to enhance the activity of agents with demonstrated clinical benefits.
Negative_regulation (inhibition) of Gene_expression (expression) of PLK-1 in bladder associated with bladder cancer
1) Confidence 0.08 Published 2008 Journal Pharm Res Section Body Doc Link PMC2440939 Disease Relevance 0.54 Pain Relevance 0

General Comments

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