INT237227

Context Info Confidence 0.08 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.54 Pain Relevance 0

cytoplasm (Plk1) mitosis (Plk1) chromosome (Plk1) nucleus (Plk1) cytoskeleton (Plk1) cell cycle (Plk1)

Anatomy Link Frequency bladder 2 Plk1 (Mus musculus)

Pain Link Frequency Relevance Heat Deep tissue 1 5.00 interstitial cystitis 1 5.00 cva 1 5.00 intrathecal 1 5.00

Disease Link Frequency Relevance Heat Bladder Cancer 30 99.36 Cancer 34 80.68 Recurrence 22 5.00 Fever 10 5.00 Disease 7 5.00 Pox Virus Infection 5 5.00 Carcinoma In Situ 3 5.00 Disease Progression 3 5.00 Immunization 2 5.00 Metastasis 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Instillation of siRNA/cationic liposomes targeting polo-like kinase-1 or PLK-1, a biomarker of poor prognosis in a murine orthotopic bladder cancer model, resulted in significant inhibition of PLK-1 expression and lowering the PLK-1 protein level in bladder tissues, in a time- and dose-dependent manner (150).Another emerging experimental approach, still in preclinical evaluation, is using chemosensitizer to enhance the activity of agents with demonstrated clinical benefits.

Negative_regulation (inhibition) of Gene_expression (expression) of PLK-1 in bladder associated with bladder cancer

1) Confidence 0.08 Published 2008 Journal Pharm Res Section Body Doc Link PMC2440939 Disease Relevance 0.54 Pain Relevance 0

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