INT237228

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.46
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CAR 2
vs (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 2 82.76 Quite High
anesthesia 4 50.40 Quite High
Deep tissue 1 11.84 Low Low
antagonist 5 8.16 Low Low
medulla 4 7.68 Low Low
Locus ceruleus 16 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 32 99.96 Very High Very High Very High
Death 22 99.00 Very High Very High Very High
Hepatitis C Virus Infection 104 96.08 Very High Very High Very High
Hyperglycemia 6 93.32 High High
Sprains And Strains 174 92.72 High High
Targeted Disruption 90 92.08 High High
Cirrhosis 24 91.92 High High
Disease 36 84.28 Quite High
Injury 2 83.40 Quite High
Sleep Disorders 139 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary experiments were performed comparing diet-induced obese (DIO) vs lean mice prior to conducting experiments on HFD-fed GhrR KO vs WT mice (Figure 1).


Positive_regulation (experiments) of Gene_expression (lean) of vs associated with obesity
1) Confidence 0.22 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.43 Pain Relevance 0
Preliminary experiments were performed comparing diet-induced obese (DIO) vs lean mice prior to conducting experiments on HFD-fed GhrR KO vs WT mice (Figure 1).


Positive_regulation (experiments) of Gene_expression (lean) of vs associated with obesity
2) Confidence 0.22 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.43 Pain Relevance 0.05
7), 0.54 for iso1 vs ctr (p?
Positive_regulation (for) of Gene_expression (0.54) of vs
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.53 Pain Relevance 0
Syn3 acts as a transfer enhancer that circumvents the need for CAR binding (119).A comparison of intravesical instillation (single administration) of viral IFN gene therapy (Ad-IFN/Syn3, recombinant replication-deficient adenovirus containing human IFN alpha-2b gene and Syn3) to intravesical IFN showed that IFN gene therapy resulted in much higher IFN concentrations (1000-times higher peak level) that were sustained for a much longer duration (96 hr or longer vs undetectable at 24 hr) in urothelial tissues (121).
Positive_regulation (resulted) of Gene_expression (undetectable) of vs in CAR
4) Confidence 0.10 Published 2008 Journal Pharm Res Section Body Doc Link PMC2440939 Disease Relevance 0.18 Pain Relevance 0
Furthermore, patients with high IL-6 had numerically (but not statistically significantly) higher maximum serum creatinine levels (242 vs 140 ?
Neg (not) Positive_regulation (levels) of Neg (not) Gene_expression (had) of vs
5) Confidence 0.08 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2885391 Disease Relevance 0.14 Pain Relevance 0
The lack of effects of IGFBP3 on cell death in this model might be due to the differences in circulating vs hypocretin cell specific IGFBP3 overexpression, or to lack of an IGFBP3 effect in the context of ataxin-induced cell degeneration, but is consistent with the notion that IGFBP3 may be proapoptotic only in specific circumstances, such as cancerous cells.
Positive_regulation (circulating) of Gene_expression (overexpression) of vs associated with death
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.98 Pain Relevance 0.04
The lack of effects of IGFBP3 on cell death in this model might be due to the differences in circulating vs hypocretin cell specific IGFBP3 overexpression, or to lack of an IGFBP3 effect in the context of ataxin-induced cell degeneration, but is consistent with the notion that IGFBP3 may be proapoptotic only in specific circumstances, such as cancerous cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of vs associated with death
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.98 Pain Relevance 0.04
27 vs >27 kg/m2), baseline alanine aminotransferase (ALT) quotient (?
Positive_regulation (quotient) of Gene_expression (alanine aminotransferase) of vs
8) Confidence 0.05 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.89 Pain Relevance 0
27 vs >27 kg/m2), baseline alanine aminotransferase (ALT) quotient (?
Positive_regulation (alanine aminotransferase) of Gene_expression (alanine aminotransferase) of vs
9) Confidence 0.05 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.89 Pain Relevance 0

General Comments

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