INT23725

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Context Info
Confidence 0.55
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 0.14
Pain Relevance 5.30

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endosome (CCKAR) endoplasmic reticulum (CCKAR) plasma membrane (CCKAR)
lysosome (CCKAR) cytoplasm (CCKAR) signal transducer activity (CCKAR)
Anatomy Link Frequency
dorsal horn 2
smooth muscle 1
spike 1
thoracic 1
CCKAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 37 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
ganglionectomy 9 99.82 Very High Very High Very High
Dorsal horn 15 99.78 Very High Very High Very High
qutenza 6 99.04 Very High Very High Very High
Deafferentation 15 98.88 Very High Very High Very High
antagonist 4 96.32 Very High Very High Very High
narcan 4 93.92 High High
tetrodotoxin 16 92.72 High High
agonist 1 92.56 High High
Disease Link Frequency Relevance Heat
Panic Disorder 1 69.24 Quite High
Anxiety Disorder 1 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In five animals, an inhibitory response, that is, a decrease in MI, was recorded, with 640 ng/kg of CCK-OP producing a 50% decrease in MI.
Gene_expression (producing) of CCK-OP
1) Confidence 0.55 Published 1989 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 2491218 Disease Relevance 0 Pain Relevance 0.31
In five animals, an inhibitory response, that is, a decrease in MI, was recorded, with 640 ng/kg of CCK-OP producing a 50% decrease in MI.
Gene_expression (producing) of CCK-OP
2) Confidence 0.47 Published 1989 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 2491218 Disease Relevance 0 Pain Relevance 0.31
In 20 animals, the same dose range of CCK-OP produced an excitatory response in the SO, increasing the SO motility index (MI = frequency of contractions x mean peak amplitude) dose-dependently (Kruskal Wallis P less than 0.05).
Gene_expression (produced) of CCK-OP
3) Confidence 0.41 Published 1989 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 2491218 Disease Relevance 0 Pain Relevance 0.20
In 20 animals, the same dose range of CCK-OP produced an excitatory response in the SO, increasing the SO motility index (MI = frequency of contractions x mean peak amplitude) dose-dependently (Kruskal Wallis P less than 0.05).
Gene_expression (produced) of CCK-OP
4) Confidence 0.41 Published 1989 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 2491218 Disease Relevance 0 Pain Relevance 0.20
Pretreatment with cholesterol-rich liposomes inhibited the transfer of CCK-1R and of CAV-3 in the endosomes by blocking CAV-3 phosphorylation. 4-Amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (inhibitor of tyrosine kinase) reproduced these effects by blocking pCAV-3 formation, increasing CAV-3 and CCK-1R sequestration in the caveolae and impairing CCK-8-induced contraction.
Gene_expression (transfer) of CCK-1R associated with cholecystokinin
5) Confidence 0.35 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.57
The increase in hepatic vagal activity produced by CCK-8 was significantly reduced by i.v. administration of 200 micrograms/kg of the CCKA receptor antagonist devazepide.
Gene_expression (produced) of CCK-8 associated with antagonist
6) Confidence 0.32 Published 1997 Journal Brain Res. Section Abstract Doc Link 9439812 Disease Relevance 0 Pain Relevance 0.12
Further, the inability of pretreatment with atropine and hexamethonium to reduce the increases in hepatic vagal activity produced by CCK-8 suggests that the latter effect was not secondary to changes in gastrointestinal motor function.
Gene_expression (produced) of CCK-8
7) Confidence 0.32 Published 1997 Journal Brain Res. Section Abstract Doc Link 9439812 Disease Relevance 0 Pain Relevance 0.12
The recovery of sP IR and CCK IR was not affected by midline myelotomy or thoracic cord transections, implying a local origin for the recovered sP IR and CCK IR.
Gene_expression (recovered) of CCK IR in thoracic
8) Confidence 0.12 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.82
The dorsal horn sP IR and CCK IR distribution and density of staining on the deafferented side were indistinguishable from those on the control side 1 month after ganglionectomy.
Gene_expression (distribution) of CCK IR in dorsal horn associated with ganglionectomy and dorsal horn
9) Confidence 0.12 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.78
Deafferentation of the cat lumbosacral dorsal horn following unilateral ganglionectomy (L2-S3) produced an ipsilateral depletion of substance P (sP) and cholecystokinin octapeptide (CCK) immunoreactivity (IR).
Gene_expression (produced) of cholecystokinin octapeptide in dorsal horn associated with ganglionectomy, dorsal horn, cholecystokinin, substance p and deafferentation
10) Confidence 0.11 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.68
In COS-7 cells expressing the cloned receptor, CCK-8-stimulated phosphatidylinositol hydrolysis and intracellular Ca2+ mobilization suggesting second messenger signaling through phospholipase C.
Gene_expression (expressing) of CCK-8-stimulated
11) Confidence 0.06 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 7681836 Disease Relevance 0.14 Pain Relevance 0.31
Cholecystokinin-octapeptide (CCK-OP) produced a contractile response in isolated guinea pig gallbladder; the response consisted of scopolamine-sensitive and scopolamine-insensitive components, neither of which were affected by tetrodotoxin or hexamethonium.
Gene_expression (produced) of CCK-OP associated with tetrodotoxin and cholecystokinin
12) Confidence 0.04 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2872623 Disease Relevance 0 Pain Relevance 0.26
Cholecystokinin octapeptide (CCK-OP) produced dose-dependent increases in the amplitude of pyloric contractions and in pyloric spike activity.
Gene_expression (produced) of CCK-OP in spike associated with cholecystokinin
13) Confidence 0.03 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 3976889 Disease Relevance 0 Pain Relevance 0.39
At least eight muscle strips were excised from each stomach: longitudinal (lo) and circular (ci) strips from fundus (Fu), corpus (Co) and antrum (An), and circular strips from the inner and outer portion of the pyloric ring. 2 Cholecystokinin 33 (CCK 33), cholecystokinin octapeptide (CCK 8), caerulein and pentagastrin produced the same pattern of responses, with differences in their potencies: caerulein was 10 times more potent than CCK 8, and CCK eight to ten times more potent than CCK 33 and pentagastrin. 3 The most characteristic effect of the CCK peptides was an increase in frequency of the phasic activity of Fu-ci, Co and An preparations (threshold 10(-10) mol/l for CCK 8), usually combined with weak or moderate increases of amplitude. 4 Slight tonic activations were observed in Fu-lo, Co-lo and An-lo (around 10% of the ACH maximum), and stronger tonic activations in Fu-ci and Co-ci (around 50% of the ACH maximum). 5 No responses to CCK were seen in pyrolic preparations. 6 Experiments with receptor antagonists (adrenoceptors, muscarinic and histamine receptors), and with tetrodotoxin indicate that the peptides act by a direct effect on smooth muscle.
Gene_expression (produced) of cholecystokinin octapeptide in smooth muscle associated with tetrodotoxin, antagonist and cholecystokinin
14) Confidence 0.00 Published 1987 Journal J Auton Pharmacol Section Abstract Doc Link 3654682 Disease Relevance 0 Pain Relevance 0.24

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