INT237257

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 18
Disease Relevance 5.15
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rhbdl1)
Rhbdl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 1552 100.00 Very High Very High Very High
depression 240 99.54 Very High Very High Very High
Hippocampus 16 85.36 High High
imagery 112 76.56 Quite High
antagonist 16 54.96 Quite High
Calcium channel 112 38.04 Quite Low
potassium channel 16 33.44 Quite Low
tetrodotoxin 48 29.64 Quite Low
Neurotransmitter 64 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papilloma 114 100.00 Very High Very High Very High
Malignant Neoplastic Disease 22 99.98 Very High Very High Very High
Depression 240 99.54 Very High Very High Very High
Cleidocranial Dysplasia 60 95.96 Very High Very High Very High
Adenocarcinoma 6 93.84 High High
Papillomavirus Infection 30 93.56 High High
Carcinoma 8 89.16 High High
Nicotine Addiction 8 83.16 Quite High
Retinitis 8 73.12 Quite High
Cytomegalovirus Infection 10 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of cidofovir in malignant degeneration of RRP remains unclear.
Gene_expression (degeneration) of RRP associated with malignant neoplastic disease and papilloma
1) Confidence 0.67 Published 2008 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2441494 Disease Relevance 1.69 Pain Relevance 0
However, spontaneous malignant degeneration of RRP is possible.
Gene_expression (degeneration) of RRP associated with malignant neoplastic disease and papilloma
2) Confidence 0.67 Published 2008 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2441494 Disease Relevance 1.90 Pain Relevance 0
To determine objectively from 100 Hz bursts the size of the RRP, in each cell we used an automated method that searched for plateaus in the ?
Spec (determine) Gene_expression (size) of RRP
3) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.34
The estimates we present for Pv (0.10) and RRP size (?
Gene_expression (size) of RRP associated with action potential
4) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.39 Pain Relevance 0.27
The estimates we present for Pv (0.10) and RRP size (?
Gene_expression (present) of RRP associated with action potential
5) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.40 Pain Relevance 0.28
Having confirmed that we had reliable methods to estimate RRP size, we could use them to calculate Pv by measuring responses to 1 AP under standard conditions (2?
Gene_expression (size) of RRP associated with action potential
6) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.47
We predicted that the larger increase in intracellular calcium would lead to a more rapid, clearly noticeable depression of exocytosis as a consequence of RRP depletion.
Gene_expression (depletion) of RRP associated with depression
7) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.24 Pain Relevance 0.12
Under these stimulation conditions we could not observe any obvious kinetic signature of depression expected from a rapid depletion of the RRP in any of the cells we tested (n?
Gene_expression (depletion) of RRP associated with depression
8) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.17 Pain Relevance 0.17
A plateau representing the RRP size was identified as the largest window where the slope of ?
Gene_expression (size) of RRP
9) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.32
High-frequency action potential bursts deplete the RRP
Gene_expression (deplete) of RRP associated with action potential
10) Confidence 0.63 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.05 Pain Relevance 0.18
The data were well fit by a generalized Hill model – Eq. 3 – where the saturation value corresponds to an estimate of the size of the RRP (5.9 ±?
Gene_expression (size) of RRP
11) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.20
We therefore estimate that, on average, the RRP corresponds to ?
Gene_expression (corresponds) of RRP
12) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.22 Pain Relevance 0.19
We also analyzed the data using only the stimulus-locked component of exocytosis (excluding the fast subcomponent of delayed release) and found that while the estimate of RRP size was ?
Gene_expression (size) of RRP
13) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.17
To determine the RRP size, we averaged the ?
Spec (determine) Gene_expression (size) of RRP
14) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.33
To estimate the RRP size from single AP data (Figure 2C), we used a generalized Hill model that relates exocytosis (Exo) and the relative increase in intracellular calcium (rCai):
Gene_expression (size) of RRP associated with action potential
15) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.22
Our methods should be widely applicable to study factors that affect Pv and RRP size.
Gene_expression (size) of RRP associated with action potential
16) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.39
An unexpected finding when developing protocols to measure the RRP size was the lack of strong depression in response to 20 or 40?
Gene_expression (size) of RRP associated with depression
17) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.10 Pain Relevance 0.42
To estimate how precisely we could determine Pv and RRP size in each cell (Figures 3E and 5B), we used a standard formula to propagate the errors arising from fluctuations in our traces (Taylor, 1997):
Spec (determine) Gene_expression (size) of RRP associated with action potential
18) Confidence 0.55 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.24

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