INT23728

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.48
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCKAR) endoplasmic reticulum (CCKAR) plasma membrane (CCKAR)
lysosome (CCKAR) cytoplasm (CCKAR) signal transducer activity (CCKAR)
Anatomy Link Frequency
upper 1
dorsal horn 1
CCKAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 11 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
antagonist 2 99.86 Very High Very High Very High
ganglionectomy 12 99.34 Very High Very High Very High
qutenza 8 99.34 Very High Very High Very High
Deafferentation 20 99.32 Very High Very High Very High
Dorsal horn 20 98.62 Very High Very High Very High
Enkephalin 4 98.34 Very High Very High Very High
vagus nerve 2 97.48 Very High Very High Very High
nud 2 91.16 High High
Disease Link Frequency Relevance Heat
Vomiting 2 96.16 Very High Very High Very High
Dyspepsia 2 91.16 High High
Pain 2 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensory experience evoked by lipid was diminished by both topical mucosal anaesthesia and CCK-A receptor blockade.
Negative_regulation (blockade) of CCK-A associated with cholecystokinin
1) Confidence 0.42 Published 1998 Journal DTW. Dtsch. Tierarztl. Wochenschr. Section Abstract Doc Link 9932012 Disease Relevance 0.48 Pain Relevance 0.41
Injection of the CCK-A receptor antagonist 2-NAP abolished both the responses to CCK-8S and to gastric distension.
Negative_regulation (abolished) of CCK-8S associated with antagonist
2) Confidence 0.24 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16047548 Disease Relevance 0 Pain Relevance 0.13
The loss of sP IR and CCK IR was most marked at 11 days postlesion, and partial recovery of sP IR and CCK IR was noted in the upper laminae of the dorsal horn ipsilateral to the lesion 14 days after deafferentation.
Negative_regulation (loss) of CCK IR in upper associated with dorsal horn and deafferentation
3) Confidence 0.10 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.69
The pattern and density of methionine-enkephalin (M-ENK) IR was not disrupted by deafferentation, demonstrating that the sP IR and CCK IR depletions were due to the deafferentation and not to nonselective vascular damage.
Negative_regulation (depletions) of CCK IR associated with enkephalin and deafferentation
4) Confidence 0.08 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.82
Deafferentation of the cat lumbosacral dorsal horn following unilateral ganglionectomy (L2-S3) produced an ipsilateral depletion of substance P (sP) and cholecystokinin octapeptide (CCK) immunoreactivity (IR).
Negative_regulation (depletion) of cholecystokinin octapeptide in dorsal horn associated with ganglionectomy, dorsal horn, cholecystokinin, substance p and deafferentation
5) Confidence 0.08 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.67
Moreover, capsaicin, a primary afferent neurotoxin, depleted sP IR and CCK IR only from the intact side.
Negative_regulation (depleted) of CCK IR associated with qutenza
6) Confidence 0.08 Published 1986 Journal Somatosens Res Section Abstract Doc Link 2428085 Disease Relevance 0 Pain Relevance 0.80

General Comments

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