INT237322

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 52
Total Number 55
Disease Relevance 21.07
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) signal transduction (Irs1) plasma membrane (Irs1)
nucleus (Irs1) cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
fat 7
skeletal muscle 5
plasma 1
muscle 1
body 1
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 151 99.48 Very High Very High Very High
tolerance 360 99.00 Very High Very High Very High
Kinase C 66 84.80 Quite High
Central nervous system 14 80.80 Quite High
ketamine 90 71.92 Quite High
anesthesia 49 60.40 Quite High
Inflammation 108 57.32 Quite High
Pyramidal cell 2 35.04 Quite Low
analgesia 1 21.80 Low Low
fibrosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 1205 100.00 Very High Very High Very High
Targeted Disruption 401 99.88 Very High Very High Very High
Obesity 505 99.72 Very High Very High Very High
Impaired Glucose Tolerance 447 99.00 Very High Very High Very High
Diabetes Mellitus 418 97.48 Very High Very High Very High
Hyperinsulinism 99 92.88 High High
Disease 118 91.84 High High
Hepatocellular Cancer 5 90.24 High High
Apoptosis 15 89.92 High High
Body Weight 205 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, our data suggest that IRS-1 serine phosphorylation does not lead to increased IRS-1 degradation by activation of the ubiquitin-proteosome or suppressor of cytokine-signaling pathway, since IRS-1 protein expression was unchanged after 8 weeks of high-fat diet treatment (Fig. 1A).
Gene_expression (expression) of IRS-1 protein in fat associated with cytokine
1) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.28 Pain Relevance 0.08
These data are also consistent with recent studies in humans demonstrating unaltered IRS-1 expression in the muscle of young lean insulin-resistant offspring of parents with type 2 diabetes (11).
Gene_expression (expression) of IRS-1 in muscle associated with diabetes mellitus
2) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.31 Pain Relevance 0.07
In contrast to these results, we did observed decreased IRS-1 protein expression in ob/ob mice compared with WT mice (Fig. 1A), suggesting that increased IRS-1 degradation may occur in the ob/ob phenotype, which is consistent with a previous study (38).
Gene_expression (expression) of IRS-1 protein associated with obesity
3) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.39 Pain Relevance 0.07
Generation of IRS-1 Ser?
Gene_expression (Generation) of IRS-1 Ser
4) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.53 Pain Relevance 0
From 25 positive founders, three lines were selected based on their protein expression of IRS-1 (approximately two times).
Gene_expression (expression) of IRS-1
5) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.40 Pain Relevance 0.11
Two lines were selected based on their protein expression of IRS-1 (approximately two times more IRS-1 protein in Tg IRS-1 WT).
Gene_expression (expression) of IRS-1 protein
6) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.36 Pain Relevance 0.07
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Gene_expression (overexpressing) of IRS-1 associated with targeted disruption
7) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.33 Pain Relevance 0.07
Two lines were selected based on their protein expression of IRS-1 (approximately two times more IRS-1 protein in Tg IRS-1 WT).
Gene_expression (expression) of IRS-1
8) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.36 Pain Relevance 0.07
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Gene_expression (overexpressing) of IRS-1 WT associated with targeted disruption
9) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.33 Pain Relevance 0.07
To analyze the effect of overexpression of mutated IRS-1 in different insulin resistance models, we tested these mice at age 1 year with an IPGTT.
Spec (analyze) Gene_expression (overexpression) of IRS-1 associated with insulin resistance
10) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.32 Pain Relevance 0.04
To assess insulin-signaling molecules, Tg IRS-1 Ser?
Gene_expression (assess) of IRS-1 Ser
11) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0 Pain Relevance 0
To examine Tg IRS-1 Ser?
Spec (examine) Gene_expression (examine) of IRS-1 Ser
12) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.24 Pain Relevance 0
Ala mice, we performed hyperinsulinemic-euglycemic clamp experiments in age-matched WT and Tg IRS-1Ser?
Gene_expression (matched) of IRS-1Ser
13) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.39 Pain Relevance 0.09
Overexpression of mutated IRS-1 improved glucose metabolism in old mice and Tg IRS-1 Ser?
Gene_expression (Overexpression) of IRS-1
14) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.23 Pain Relevance 0.04
We also detected a 20% increase in IRS-1┬ľassociated PI3-kinase activity (Fig. 3D) of Tg IRS-1 Ser?
Gene_expression (activity) of IRS-1 Ser
15) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.06 Pain Relevance 0
To address whether the IRS-1 Ser?
Gene_expression (address) of IRS-1 Ser
16) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.40 Pain Relevance 0.04
Ala mutation of IRS-1 and not on the overexpression of IRS-1 per se, we also generated mice with a similar twofold overexpression of WT IRS-1 (Tg IRS-1 WT) in skeletal muscle as an alternative control.
Gene_expression (overexpression) of IRS-1 in skeletal muscle
17) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.40 Pain Relevance 0.04
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Neg (except) Gene_expression (expression) of IRS-1 WT associated with targeted disruption
18) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.38 Pain Relevance 0.07
In contrast, there were no differences in insulin-mediated suppression of hepatic glucose production between the Tg IRS-1 Ser?
Gene_expression (suppression) of IRS-1 Ser
19) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.19 Pain Relevance 0.06
Briefly, we backcrossed Tg IRS-1 Ser?
Gene_expression (backcrossed) of IRS-1 Ser
20) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

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