INT237337

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.63
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav3) plasma membrane organization (Cav3) plasma membrane (Cav3)
enzyme binding (Cav3) protein complex (Cav3) cytoplasm (Cav3)
Anatomy Link Frequency
muscle 1
Cav3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 8 85.04 High High
imagery 14 72.80 Quite High
cytokine 7 69.56 Quite High
Sciatic nerve 1 13.76 Low Low
Inflammation 18 11.48 Low Low
tolerance 4 7.04 Low Low
Dopamine 20 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lipodystrophy 24 100.00 Very High Very High Very High
Muscle Disease 21 98.68 Very High Very High Very High
Obesity 22 96.56 Very High Very High Very High
Targeted Disruption 11 93.52 High High
Dyslipidemia /

Combined Dyslipidemia

8 90.40 High High
Impaired Glucose Tolerance 6 89.28 High High
INFLAMMATION 28 84.64 Quite High
Injury 9 82.00 Quite High
Toxicity 6 78.52 Quite High
Congenital Generalized Lipodystrophy 22 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Absence of PTRF-CAVIN did not influence abundance of its binding partner caveolin-1 and caveolin-3.
caveolin-3 Binding (binding) of
1) Confidence 0.44 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2837386 Disease Relevance 1.16 Pain Relevance 0.04
This gene was an attractive candidate because it had been shown to interact with caveolin-1 [16], whose mutations cause lipodystrophy [5] and with caveolin-3, whose mutations cause rippling muscle disease [17].
caveolin-3 Binding (interact) of in muscle associated with muscle disease and lipodystrophy
2) Confidence 0.44 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.78 Pain Relevance 0
We found that, in both conditions, myotubularin is distributed in the cytosolic S3 fraction, containing glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and in the membrane P3 fraction, containing caveolin 3 (which is associated with sarcolemmal caveolae) (Fig. 5D).
caveolin 3 Binding (associated) of
3) Confidence 0.29 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.11 Pain Relevance 0
To date, 3 caveolins (Cav-1, Cav-2, and Cav-3) with unique tissue distribution have been characterized.
Cav-3 Binding (characterized) of
4) Confidence 0.04 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.49 Pain Relevance 0.08

General Comments

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