INT237340

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Mtm1) endosome (Mtm1) transport (Mtm1)
plasma membrane (Mtm1) cytoplasm (Mtm1)
Anatomy Link Frequency
muscle 3
skeletal muscle 1
Mtm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 5 100.00 Very High Very High Very High
Inflammation 10 98.06 Very High Very High Very High
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 98.06 Very High Very High Very High
Muscle Weakness 20 97.40 Very High Very High Very High
Disease 25 94.80 High High
Death 10 89.12 High High
Cytomegalovirus Infection 65 85.68 High High
Congenital Structural Myopathies 85 84.68 Quite High
Demyelinating Disease 10 81.76 Quite High
Charcot Marie Tooth Disease 20 80.64 Quite High
Muscle Hypotonia 5 57.76 Quite High
Muscle Disease 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Occasional small foci of inflammatory infiltrates were observed in AAV-transduced mKO muscles, often nearby myofibers expressing high levels of myotubularin (Fig. 3C).
Positive_regulation (levels) of myotubularin in muscles associated with inflammation
1) Confidence 0.60 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.36 Pain Relevance 0.05
The same phenotype is observed when the Mtm1 gene is inactivated only in skeletal muscle, indicating that myotubularin exerts a muscle autonomous function (12).
Positive_regulation (inactivated) of Mtm1 in muscle
2) Confidence 0.50 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.68 Pain Relevance 0
Myotubularin is ubiquitously expressed in mouse tissues, being more abundant in striated muscles than in sciatic nerve and brain, and increases during the first postnatal week in skeletal muscle (Supplementary Material, Fig.
Positive_regulation (increases) of Myotubularin in skeletal muscle associated with sciatic nerve
3) Confidence 0.46 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0.05
We tested whether AAV-mediated myotubularin replacement could be beneficial at the functional level because muscle weakness is the constant and life threatening sign of the disease.
Positive_regulation (mediated) of myotubularin in muscle associated with muscle weakness and disease
4) Confidence 0.44 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.42 Pain Relevance 0.04
We found that, in both conditions, myotubularin is distributed in the cytosolic S3 fraction, containing glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and in the membrane P3 fraction, containing caveolin 3 (which is associated with sarcolemmal caveolae) (Fig. 5D).
Positive_regulation (distributed) of myotubularin
5) Confidence 0.40 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.06 Pain Relevance 0

General Comments

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